Brodalumab (Biosimilar Reference Antibody) (IL17RA)
Brodalumab (Biosimilar Reference Antibody) (IL17RA)
Brodalumab (Biosimilar Reference Antibody) (IL17RA)-RA0352-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Brodalumab (Biosimilar Reference Antibody) (IL17RA)-RA0352 in a linear range of 3.91-125 ng/mL.
Brodalumab (Biosimilar Reference Antibody) (IL17RA)

Catalog: 

RA0352

Target

IL17RA/CD217

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Brodalumab is a fully human monoclonal antibody used in the treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis. It was first approved for medical use in 2017 and is marketed under the brand name Siliq® in the United States and Kyntheum® in the European Union. As an interleukin-17 receptor antagonist, brodalumab works by binding to and blocking the activity of a specific inflammatory pathway. While highly effective, its prescribing information includes a Boxed Warning—the most serious type of FDA warning—due to an observed risk of suicidal ideation and behavior, requiring specific risk evaluation and mitigation strategies (REMS).

Synonyms

AMG827, KHK4827

CAS

1174395-19-7

Isotype

IgG2 - kappa

Host

Genetically human

Target

IL17RA/CD217

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Papp KA, et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med. 2012 Mar 29;366(13):1181-9.

References 2

Martin DA, et al. A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis. Arthritis Res Ther. 2013 Oct 25;15(5):R164.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/22455412/
https://pubmed.ncbi.nlm.nih.gov/24286136/
https://www.oursmab.com/News/The-key-hub-for-inflammation-regulation-IL17R.html

Target Description

Synonyms

interleukin 17 receptor A, CD217

Biology Area

Cytokine and Chemokine;CD Markers;Immunology

Function

Interleukin-17 receptor A (IL-17RA), a protein subunit found on the surface of cells. IL-17RA is part of the signaling pathway for several pro-inflammatory cytokines, including IL-17A, IL-17F, IL-17C, and IL-17E (IL-25).

Additional Articles 1

The-key-hub-for-inflammation-regulation-IL17R

Additional Articles 2

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