Tumor microenvironment proinflammatory factors S100A8-S100A9
S100A8 and S100A9 are both calcium and zinc binding proteins and key members of the S100 protein family. They have a variety of immunomodulat...
The tight junction protein CLDN6
Claudin-6 (CLDN6) is a crucial component of tight junctions (TJs), exhibiting a typical carcinoembryonic expression pattern. It is largely ab...
Insulin-like growth factor IGF1 and IGF2
Insulin-derived growth factors mainly include insulin-like growth factor 1 (IGF1) and insulin-like growth factor 2 (IGF2), which are core lig...
Prostate cancer therapeutic target KLK2
KLK2 is a secreted serine protease, a prostate cancer tissue-specific protein regulated by androgen receptor ( AR ) signaling. KLK2 plays a c...
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila
On September 23, 2026, Zongzhao Zhai (Hunan Normal University) and Yirong Wang and Jiongming Lu (Hunan University)—serving as co-correspondin...
Therapeutic Target for Itching and Inflammatory Diseases IL31RA
Interleukin-31 receptor subunit α (IL31RA), also known as cytokine receptor-like 3, Gp130-like monocyte receptor (GLM-R), CRL3, or GPL, forms...
Complement cascade amplification initiation enzyme C2
Complement C2 is a precursor to the C3 and C5 convertase complex catalytic component of the complement pathway. Component C2 is part of the c...
The bidirectional signaling integrin ITGA5B1
Integrin α5β1 (ITGA5B1) is a key signaling protein between cells and the extracellular matrix, formed by the nonvalent binding of the α5 subu...
Tumor specific glycolipid antigen NeuGcGM3
Mannoceramide GM3 is a fundamental glycolipid on the surface of mammalian cells and a key regulator of transmembrane signaling and cell recog...