Tocilizumab (Biosimilar Reference Antibody) (IL6R)
Tocilizumab (Biosimilar Reference Antibody) (IL6R)
Tocilizumab (Biosimilar Reference Antibody) (IL6R)-RA0408-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tocilizumab biosimilar in a linear range of 15.63-500 ng/mL.
Tocilizumab (Biosimilar Reference Antibody) (IL6R)

Catalog: 

RA0408

Target

IL6R/CD126

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tocilizumab is a humanized monoclonal antibody targeting the interleukin-6 receptor (IL-6R), binding to both soluble and membrane-bound forms. It inhibits IL-6-mediated pro-inflammatory signaling and is approved for rheumatoid arthritis, systemic juvenile idiopathic arthritis, giant cell arteritis, cytokine release syndrome, and severe COVID-19.

Synonyms

atlizumab, MRA, rhPM-1

CAS

375823-41-9

Isotype

IgG1 - kappa

Host

Humanised

Target

IL6R/CD126

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70.

References 2

Mami Noda, et al. IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung Tumor Cells in the Brain. Int J Mol Sci. 2013 Jan; 14(1): 515–526.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/21990364/
https://pubmed.ncbi.nlm.nih.gov/23271367/
https://www.oursmab.com/News/polygenic-proinflammatory-cytokine-IL6.html

Target Description

Synonyms

interleukin 6 receptor, IL-6R, CD126

Biology Area

Cytokine Receptor;Immunology;CD Markers

Function

IL-6R, is a key mediator of acute and chronic inflammation. By blocking IL-6R, tocilizumab reduces downstream effects like fever, CRP elevation, and tissue damage. Its broad use highlights the central role of IL-6 in immune dysregulation, from autoimmune diseases to hyperinflammatory states.

Additional Articles 1

polygenic-proinflammatory-cytokine-IL6

Additional Articles 2

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