Icatolimab (Biosimilar Reference Antibody) (BTLA)
Icatolimab (Biosimilar Reference Antibody) (BTLA)
Icatolimab (Biosimilar Reference Antibody) (BTLA)-RA0827-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Icatolimab biosimilar in a linear range of 3.91-500 ng/mL.
Icatolimab (Biosimilar Reference Antibody) (BTLA)

Catalog: 

RA0827

Target

BTLA/CD272

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4601

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Icatolimab (TAB004/JS004) is a humanized recombinant IgG4 monoclonal antibody against B- and T-lymphocyte attenuation factor (BTLA). In vitro and in vivo studies have shown TAB004 or JS004 can promote antigen specific T cell proliferation and effector function, reduce tumor burden and improve survival in human BTLA knock-in tumor models.

Synonyms

JS004,JS-004,JS 004,TAB004,TAB-004,TAB 004,Tifcemalimab

CAS

2236068-83-8

Isotype

IgG1 - kappa

Host

Chimeric

Target

BTLA/CD272

Reactivity

Human

Expression System

CHO

Applications

ELISA;FC;Functional Assays;IF

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Bosch F, Dalla-Favera R (2019) Chronic lymphocytic leukaemia: from genetics to treatment. Nat Rev Clin Oncol 16:684–701.

References 2

Burger JA, O’Brien S (2018) Evolution of CLL treatment - from chemoimmunotherapy to targeted and individualized therapy. Nat Rev Clin Oncol 15:510–527.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.2643
https://www.oursmab.com/News/B-and-T-lymphocyte-attenuator-BTLA.html

Target Description

Synonyms

BTLA; CD272

Biology Area

Immunology;Immune Checkpoint;CD Markers

Function

BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.

Additional Articles 1

B-and-T-lymphocyte-attenuator-BTLA

Additional Articles 2

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