Pacanalotamab (Biosimilar Reference Antibody) (BCMA TNFRSF17&CD3E)
Pacanalotamab(Biosimilar Reference Antibody) (BCMA/TNFRSF17 & CD3E)-RA0828-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Pacanalotamab (Biosimilar Reference Antibody) (BCMA TNFRSF17&CD3E)

Catalog: 

RA0828

Target

BCMA/TNFRSF17

Isotype

(scFv-heavy-kappa)-(scFv-heavy-lambda)

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-100;1 mg-420;5 mg-1000;10 mg-1600;25 mg-3500;50 mg-6000;100 mg-9200

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Pacanalotamab is a bispecific T-cell engager (BiTE®) antibody construct targeting B cell maturation antigen (BCMA) and CD3ε. By bridging T cells and BCMA-expressing multiple myeloma cells, Pacanalotamab promotes potent T cell–mediated cytotoxicity. It is a valuable tool for preclinical evaluation of immune cell redirection and targeted therapies in hematologic malignancies.

Synonyms

AMG 420，BI-836909

CAS

2251756-52-0

Isotype

(scFv-heavy-kappa)-(scFv-heavy-lambda)

Host

Chimeric Humanized

Target

BCMA/TNFRSF17

Reactivity

Human

Expression System

CHO

Applications

ELISA;FC;Functional Assays;IF

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Hipp S, et al. A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo. Leukemia. 2017 Aug;31(8):1743-1751.

References 2

Topp et al., 2020. Anti-B-Cell Maturation Antigen BiTE Molecule AMG 420 Induces Responses in Multiple Myeloma. J Clin Oncol. 2020 Mar 10;38(8):775-783.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/28025583/
https://pubmed.ncbi.nlm.nih.gov/31895611/

Target Description

Synonyms

Biology Area

Hematology;Immunology

Function

BCMA (TNFRSF17/CD269) supports survival of malignant plasma cells; CD3E: TCR‑complex signalling subunit. Bispecific cross‑linking of BCMA and CD3E activates T‑cells for MHC‑independent lysis of BCMA‑positive tumour cells.

Additional Articles 1

Additional Articles 2

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Catalog: 

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Target：

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Isotype：

(scFv-heavy-kappa)-(scFv-heavy-lambda)

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
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Target：

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Isotype：

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Reactivities：

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Catalog: 

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Target：

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Isotype：

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Reactivities：

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Reactivities：

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