Bempikibart (Biosimilar Reference Antibody) (IL7R)
Bempikibart (Biosimilar Reference Antibody) (IL7R)
Bempikibart (Biosimilar Reference Antibody) (IL7R)-RA0409-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Bempikibart (Biosimilar Reference Antibody) (IL7R)-RA0409 in a linear range of 3.91-31.25 ng/mL.
Bempikibart (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0409

Target

IL7R/CD127

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Bempikibart (also known as ADX-914) is a fully human monoclonal antibody designed to act as an antagonist by selectively targeting the Interleukin-7 receptor alpha subunit (IL-7Ralpha). Its mechanism is unique as the IL-7Ralpha subunit is a shared component of two distinct, critical signaling pathways: those driven by Interleukin-7 (IL-7) and Thymic Stromal Lymphopoietin (TSLP). By binding to and blocking IL-7Ralpha, Bempikibart achieves simultaneous inhibition of both the IL-7 and TSLP signaling pathways. This dual blockade is intended to suppress the pathogenic activity of various T-helper cell subtypes (Th1 and Th2) and related downstream inflammation.

Synonyms

ADX-914

CAS

2622254-57-1

Isotype

IgG1 - kappa

Host

Genetically human

Target

IL7R/CD127

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Bick F, et al. Targeting γc family cytokines with biologics: current status and future prospects. MAbs. 2025 Dec;17(1):2468312.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/39967341/
https://www.oursmab.com/News/Interleukin-7-receptor-alpha-subunit-CD127.html

Target Description

Synonyms

interleukin 7 receptor, IL7RA, CD127

Biology Area

Immunology;CD Markers;Cytokine Receptor

Function

Interleukin-7 Receptor Alpha subunit (IL-7Rα, also known as CD127). IL-7Rα pairs with the common gamma chain (γc) to form the functional receptor for IL-7, and it pairs with the TSLP receptor (TSLPR) chain to form the functional receptor for TSLP.

Additional Articles 1

Interleukin-7-receptor-alpha-subunit-CD127

Additional Articles 2

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