Pogalizumab (Biosimilar Reference Antibody) (TNFRSF4)
Pogalizumab (Biosimilar Reference Antibody) (TNFRSF4)-RA0829-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Pogalizumab (Biosimilar Reference Antibody) (TNFRSF4)

Catalog: 

RA0829

Target

TNFRSF4/CD134/OX40

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Pogalizumab is an investigational humanized monoclonal antibody that targets and acts as an agonist of the co-stimulatory receptor OX40 (CD134). It is designed for cancer immunotherapy, with the goal of enhancing anti-tumor immune responses by directly activating OX40-positive T cells, thereby promoting their proliferation, survival, and effector function.

Synonyms

MOXR-0916, RG-7888, MOXR0916, RO7021608

CAS

1638935-72-4

Isotype

IgG1 - kappa

Host

Humanised

Target

TNFRSF4/CD134/OX40

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Holay N, et al. INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering. J Immunother Cancer. 2025 May 21;13(5):e011524.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/40404202/
https://www.oursmab.com/News/T-cell-costimulatory-molecule-OX40.html

Target Description

Synonyms

tumor necrosis factor receptor (TNFR) superfamily member 4, OX40, CD134

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

OX40 (also known as CD134 or TNFRSF4) is a co-stimulatory receptor belonging to the tumor necrosis factor receptor superfamily (TNFRSF). It is transiently and selectively expressed on activated CD4+ and CD8+ T cells, as well as on regulatory T cells (Tregs) and natural killer (NK) cells. OX40 is not present on naïve or resting T cells.

Additional Articles 1

T-cell-costimulatory-molecule-OX40

Additional Articles 2

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