Cusatuzumab (Biosimilar Reference Antibody) (CD70)
Cusatuzumab (Biosimilar Reference Antibody) (CD70)
Cusatuzumab (Biosimilar Reference Antibody) (CD70)-RA0129-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Cusatuzumab (Biosimilar Reference Antibody) (CD70)-RA0129 in a linear range of 0.18-125 ng/mL.
Cusatuzumab (Biosimilar Reference Antibody) (CD70)

Catalog: 

RA0129

Target

CD70

Isotype

IgG1 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Cusatuzumab (also known as ARGX-110) is an investigational humanized monoclonal antibody developed as a targeted therapy for hematologic malignancies, particularly acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). It is designed to eliminate leukemia stem cells and immature malignant blasts that express a specific surface antigen, aiming to address a root cause of disease persistence and relapse. Clinical trials have evaluated its use, often in combination with hypomethylating agents like azacitidine, for the treatment of patients with newly diagnosed or relapsed/refractory AML who are unfit for intensive chemotherapy.

Synonyms

ARGX-110

CAS

1864871-20-4

Isotype

IgG1 - lambda

Host

Humanised

Target

CD70

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Riether C, et al. Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents. Nat Med. 2020; 26(9):1459-1467.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32601337/
https://www.oursmab.com/News/Tumor-immune-regulator-CD70.html

Target Description

Synonyms

tumor necrosis factor (TNF) superfamily member 7, TNFSF7, CD27LG, CD27L

Biology Area

Immunology;CD Markers;Cancer Biology;CD Markers

Function

CD70, a cell surface protein belonging to the tumor necrosis factor (TNF) superfamily. CD70 is the ligand for the receptor CD27. In normal physiology, the CD70-CD27 interaction provides a co-stimulatory signal for T-cell and B-cell activation. However, in many hematologic and solid tumors, CD70 is aberrantly and highly expressed on cancer cells, including leukemia stem cells. This expression can promote tumor cell survival, proliferation, and immunosuppression.

Additional Articles 1

Tumor-immune-regulator-CD70

Additional Articles 2

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