Datopotamab (Biosimilar Reference Antibody) (TROP2)
Datopotamab (Biosimilar Reference Antibody) (TROP2)
Datopotamab (Biosimilar Reference Antibody) (TROP2)-RA0802-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Datopotamab (Biosimilar Reference Antibody) (TROP2)-RA0802 in a linear range of 3.91-125 ng/mL.
Datopotamab (Biosimilar Reference Antibody) (TROP2)

Catalog: 

RA0802

Target

TROP2

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Datopotamab deruxtecan (also known as Dato-DXd or DS-1062) is an investigational antibody-drug conjugate (ADC) developed for the treatment of advanced solid tumors, most notably non-small cell lung cancer (NSCLC) and triple-negative breast cancer (TNBC). It is composed of a humanized monoclonal antibody directed against TROP2, a linker, and a potent topoisomerase I inhibitor payload. Clinical trials have demonstrated promising efficacy in patients with heavily pretreated disease, leading to its Breakthrough Therapy Designation in the U.S. for certain NSCLC and breast cancer indications.

Synonyms

DS-1062, DS-1062a

CAS

2267989-53-5

Isotype

IgG1 - kappa

Host

Humanised

Target

TROP2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Okajima D, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Dec;20(12):2329-2340.

References 2

Daisuke Okajima, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Aug 19.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34413126/
https://pubmed.ncbi.nlm.nih.gov/34413126/
https://www.oursmab.com/News/Trophoblast-cell-surface-antigen-TROP2.html

Target Description

Synonyms

tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epithelial glycoprotein-1, EGP-1, trophoblast antigen-2, cell surface glycoprotein Trop-2, TACSTD2

Biology Area

Tumor Antigens;Cancer Biology

Function

Trophoblast cell-surface antigen 2 (TROP2), a transmembrane glycoprotein that is highly overexpressed in a wide range of epithelial cancers (e.g., lung, breast, ovarian, pancreatic) but has limited expression in normal tissues. TROP2 plays a role in promoting tumor cell growth, invasion, and metastasis. The ADC binds to TROP2 on the tumor cell surface and is internalized.

Additional Articles 1

Trophoblast-cell-surface-antigen-TROP2

Additional Articles 2

Related Products

Anti-Human CD274/PDL1/B7H1 Antibody (22C3)

Catalog: 

RA0802

Target：

CD274/PDL1/B7H1

Isotype：

IgG - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Bempikibart (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0802

Target：

IL7R/CD127

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Maftivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0802

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Lusvertikimab (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0802

Target：

IL7R/CD127

Isotype：

IgG4 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Odesivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0802

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Porgaviximab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0802

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Enokizumab (Biosimilar Reference Antibody) (IL9)

Catalog: 

RA0802

Target：

IL9

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Bapotulimab (Biosimilar Reference Antibody) (ILDR2)

Catalog: 

RA0802

Target：

ILDR2

Isotype：

IgG2 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Atoltivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0802

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Tocilizumab (Biosimilar Reference Antibody) (IL6R)

Catalog: 

RA0802

Target：

IL6R/CD126

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human

Contact Us

Send your request

Talk to us 

Get a quotation, discuss your requirement, receive advises from our antibody experts without obligation.