Enavatuzumab (Biosimilar Reference Antibody) (TNFRSF12A)
Enavatuzumab (Biosimilar Reference Antibody) (TNFRSF12A)
Enavatuzumab (Biosimilar Reference Antibody) (TNFRSF12A)-RA0756-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Enavatuzumab (Biosimilar Reference Antibody) (TNFRSF12A)-RA0756 in a linear range of 3.91-125 ng/mL.
Enavatuzumab (Biosimilar Reference Antibody) (TNFRSF12A)

Catalog: 

RA0756

Target

TNFRSF12A/CD266/TWEAKR

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Enavatuzumab is an investigational, humanized immunoglobulin G1 (IgG1) monoclonal antibody developed for the treatment of advanced solid tumors. It functions as a targeted agent against the TWEAK receptor (TweakR) with a dual mechanism of action. First, upon binding to TweakR on the surface of tumor cells, it can induce direct anti-proliferative and pro-apoptotic signaling within the cancer cell itself. Second, leveraging its IgG1 Fc domain, it engages the immune system to eliminate tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This combined approach aims to inhibit tumor growth both by intrinsic signaling blockade and extrinsic immune-mediated killing.

Synonyms

PDL 192

CAS

1062149-33-0

Isotype

IgG1 - kappa

Host

Humanised

Target

TNFRSF12A/CD266/TWEAKR

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Shiming Ye, et al. Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells. J Immunol Res. 2017;2017:5737159.

References 2

Ludmilla de Plater, et al. Predictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenografts. PLoS One. 2014 Nov 6;9(11):e104227.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/29075649/
https://pubmed.ncbi.nlm.nih.gov/25375638/
https://www.oursmab.com/News/Tumor-necrosis-factor-superfamily-receptor-TWEAKR.html

Target Description

Synonyms

tumor necrosis factor receptor (TNFR) superfamily member 12A, fibroblast growth factor (FGF)-inducible 14 kDa protein, Fn14, TNF-like weak inducer of apoptosis (Tweak) receptor, Tweak receptor, TweakR, CD266

Biology Area

Cancer Biology;Immunology;CD Markers

Function

TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily Member 12A), also known as FN14 (Fibroblast Growth Factor-inducible 14) or TWEAKR (TNF-like Weak Inducer of Apoptosis Receptor), is a cell surface receptor that plays a key role in tissue repair, inflammation, fibrosis, and cancer progression.

Additional Articles 1

Tumor-necrosis-factor-superfamily-receptor-TWEAKR

Additional Articles 2

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