Erlizumab (Biosimilar Reference Antibody) (ITGB2)
Erlizumab (Biosimilar Reference Antibody) (ITGB2)
Erlizumab (Biosimilar Reference Antibody) (ITGB2)-RA0434-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Erlizumab (Biosimilar Reference Antibody) (ITGB2)-RA0434 in a linear range of 3.91-125 ng/mL.
Erlizumab (Biosimilar Reference Antibody) (ITGB2)

Catalog: 

RA0434

Target

ITGB2/CD18

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Erlizumab (development code rhuMAb-CD18) was an investigational, humanized monoclonal IgG1 antibody developed for the treatment of acute conditions involving inflammatory tissue damage, such as stroke and myocardial infarction (heart attack). It functioned as a leukocyte adhesion inhibitor. Its proposed mechanism of action was to bind to the CD18 subunit of leukocyte integrins on the surface of neutrophils and other white blood cells. This binding aimed to block the critical interaction between these integrins (like LFA-1 and Mac-1) and adhesion molecules (ICAM-1) on activated vascular endothelial cells. By inhibiting leukocyte adhesion and subsequent transmigration into ischemic or inflamed tissues, erlizumab was designed to reduce the secondary inflammatory damage that exacerbates primary injury in stroke and heart attack.

Synonyms

rhuMAb

CAS

211323-03-4

Isotype

IgG1 - kappa

Host

Humanised

Target

ITGB2/CD18

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Nigam A, et al. Therapeutic potential of monoclonal antibodies in myocardial reperfusion injury. Am J Cardiovasc Drugs. 2002;2(6):367-76.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/14727952/
https://www.oursmab.com/News/The-cell-adhesion-molecule-ITGB2.html

Target Description

Synonyms

integrin beta2 subunit, LFA-1, MAC-1, CD18

Biology Area

Immunology;CD Markers

Function

CD18, also known as integrin beta-2 (β2). CD18 is a subunit common to several leukocyte-specific integrin heterodimers, most notably Lymphocyte Function-Associated Antigen-1 (LFA-1, αLβ2) and Macrophage-1 Antigen (Mac-1, αMβ2). These integrins are expressed on all leukocytes and play a fundamental role in the inflammatory response. Under inflammatory conditions, endothelial cells upregulate adhesion molecules like Intercellular Adhesion Molecule-1 (ICAM-1).

Additional Articles 1

The-cell-adhesion-molecule-ITGB2

Additional Articles 2

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