Indusatumab (Biosimilar Reference Antibody) (GUCY2C)
Indusatumab (Biosimilar Reference Antibody) (GUCY2C)
Indusatumab (Biosimilar Reference Antibody) (GUCY2C)-RA0280-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Indusatumab (Biosimilar Reference Antibody) (GUCY2C)-RA0280 in a linear range of 15.63–31 ng/mL.
Indusatumab (Biosimilar Reference Antibody) (GUCY2C)

Catalog: 

RA0280

Target

GUCY2C

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Indusatumab (also known as the 5F9 monoclonal antibody) is an investigational monoclonal antibody specifically targeting human guanylate cyclase 2C (GUCY2C). It is being developed as a targeted therapeutic agent, with the potential for use in two primary modalities. First, as a naked antibody, it may inhibit GUCY2C signaling or mark GUCY2C-expressing cells for immune-mediated destruction. Second, and notably, it can be used to synthesize antibody-drug conjugates (ADCs).

Synonyms

5F9, MLN2045

CAS

1497400-26-6

Isotype

IgG1 - kappa

Host

Genetically human

Target

GUCY2C

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

e Goeij BE, et al. New developments for antibody-drug conjugate-based therapeutic approaches. Curr Opin Immunol. 2016 Jun;40:14-23.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/26963132/
https://www.oursmab.com/News/Human-guanylate-cyclase-GUCY2C.html

Target Description

Synonyms

guanylate cyclase 2C, guanylyl cyclase C, GCC, guanylate cyclase C, GC-C, heat-stable enterotoxin receptor, hSTAR, intestinal guanylate cyclase

Biology Area

Tumor Antigens;Cancer Biology

Function

Guanylate cyclase 2C (GUCY2C), also known as the heat-stable enterotoxin receptor (STAR). GUCY2C is a transmembrane receptor guanylyl cyclase. In normal physiology, it is selectively and exclusively expressed on the apical surface of intestinal epithelial cells from the duodenum to the rectum. Its natural ligands are the paracrine hormones guanylin and uroguanylin, which regulate fluid and electrolyte homeostasis.

Additional Articles 1

Human-guanylate-cyclase-GUCY2C

Additional Articles 2

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