Izastobart (Biosimilar Reference Antibody) (C5AR1)
Izastobart (Biosimilar Reference Antibody) (C5AR1)
Izastobart (Biosimilar Reference Antibody) (C5AR1)-RA0057-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Izastobart (Biosimilar Reference Antibody) (C5AR1)-RA0057 in a linear range of 0.18–15 ng/mL.
Izastobart (Biosimilar Reference Antibody) (C5AR1)

Catalog: 

RA0057

Target

C5AR1

Isotype

IgG1 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Izastobart is a humanized IgG1λ2 monoclonal antibody that specifically targets the C5a receptor 1 (C5aR1 or CD88). As an IgG1 isotype, it is engineered to potentially engage effector functions such as antibody-dependent cellular cytotoxicity (ADCC). Its primary mechanism is to block the interaction between the complement anaphylatoxin C5a and its receptor C5aR1. By inhibiting this potent pro-inflammatory signaling axis, Izastobart aims to dampen the dysregulated complement activity and neutrophil-driven inflammation that are central to the pathology of autoimmune and inflammatory diseases. It is currently under clinical investigation for conditions such as hidradenitis suppurativa.

Synonyms

CAS

2769937-42-8

Isotype

IgG1 - lambda

Host

Genetically human

Target

C5AR1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Izastobart

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1485
https://www.oursmab.com/News/The-anaphylatoxin-receptor-C5AR1.html

Target Description

Synonyms

complement C5a receptor 1, C5R1, CD88

Biology Area

Immunology;Innate Immunity;CD Markers

Function

C5a receptor 1 (C5aR1 or CD88) is a G protein-coupled receptor (GPCR) that is predominantly expressed on the surface of myeloid cells, including neutrophils, monocytes, macrophages, and mast cells. It is the high-affinity receptor for the complement activation peptide C5a.

Additional Articles 1

The-anaphylatoxin-receptor-C5AR1

Additional Articles 2

Related Products

Icatolimab (Biosimilar Reference Antibody) (BTLA)

Catalog: 

RA0057

Target：

BTLA/CD272

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Emicizumab (Biosimilar Reference Antibody) (F9/Factor IX)

Catalog: 

RA0057

Target：

F9/Factor IX

Isotype：

IgG4 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Maftivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0057

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Lusvertikimab (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0057

Target：

IL7R/CD127

Isotype：

IgG4 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Odesivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0057

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Porgaviximab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0057

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Enokizumab (Biosimilar Reference Antibody) (IL9)

Catalog: 

RA0057

Target：

IL9

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Bapotulimab (Biosimilar Reference Antibody) (ILDR2)

Catalog: 

RA0057

Target：

ILDR2

Isotype：

IgG2 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Atoltivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0057

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Tocilizumab (Biosimilar Reference Antibody) (IL6R)

Catalog: 

RA0057

Target：

IL6R/CD126

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human

Contact Us

Send your request

Talk to us 

Get a quotation, discuss your requirement, receive advises from our antibody experts without obligation.