Pulocimab (Biosimilar Reference Antibody) (KDR)
Pulocimab (Biosimilar Reference Antibody) (KDR)
Pulocimab (Biosimilar Reference Antibody) (KDR)-RA0438-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Pulocimab biosimilar in a linear range of 3.91-500 ng/mL.
Pulocimab (Biosimilar Reference Antibody) (KDR)

Catalog: 

RA0438

Target

KDR/CD309/VEGFR2

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Pulocimab is a humanized IgG1 monoclonal antibody targeting VEGFR-2 (KDR). It works by binding to and blocking this key receptor for vascular endothelial growth factor (VEGF), thereby inhibiting the signaling pathway that promotes tumor angiogenesis (new blood vessel formation). This action aims to starve tumors of oxygen and nutrients, suppressing their growth and metastasis in various solid cancers.

Synonyms

AK109, AK-109, AK 109

CAS

2428381-49-9

Isotype

IgG1 - kappa

Host

Genetically human

Target

KDR/CD309/VEGFR2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Keam SJ. Cadonilimab: First Approval. Drugs. 2022 Aug;82(12):1333-1339.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/35986837/
https://www.oursmab.com/News/Vascular-endothelial-growth-factor-receptor-VEGFR2.html

Target Description

Synonyms

kinase insert domain receptor, vascular endothelial growth factor receptor 2, VEGFR2, VEGF-R2, FLK1, CD309

Biology Area

Cancer Biology;Angiogenesis;CD Markers

Function

Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), is primarily expressed on vascular endothelial cells. It is the main mediator of VEGF-driven angiogenesis, a process crucial for tumor survival and spread. By inhibiting VEGFR-2, pulocimab blocks downstream pro-angiogenic signals, leading to reduced endothelial cell proliferation and new blood vessel formation within tumors.

Additional Articles 1

Vascular-endothelial-growth-factor-receptor-VEGFR2

Additional Articles 2

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