Ramucirumab (Biosimilar Reference Antibody) (KDR)
Ramucirumab (Biosimilar Reference Antibody) (KDR)
Ramucirumab (Biosimilar Reference Antibody) (KDR)-RA0439-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Ramucirumab (Biosimilar Reference Antibody) (KDR)-RA0439 in a linear range of 15.63–125 ng/mL.
Ramucirumab (Biosimilar Reference Antibody) (KDR)

Catalog: 

RA0439

Target

KDR/CD309/VEGFR2

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Ramucirumab is a fully human IgG1 monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR-2). It blocks the binding of VEGF ligands to VEGFR-2, inhibiting angiogenesis (new blood vessel formation) and thereby starving tumors of oxygen and nutrients. It is approved for the treatment of advanced gastric, colorectal, lung, and hepatocellular cancers.

Synonyms

1121B, IMC-1121B, LY3009806

CAS

947687-13-0

Isotype

IgG1 - kappa

Host

Genetically human

Target

KDR/CD309/VEGFR2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Fala L. Cyramza (Ramucirumab) Approved for the Treatment of Advanced Gastric Cancer and Metastatic Non-Small-Cell Lung Cancer. Am Health Drug Benefits. 2015 Mar;8(Spec Feature):49-53.

References 2

Oholendt AL, et al. Ramucirumab: A New Therapy for Advanced Gastric Cancer. J Adv Pract Oncol. 2015 Jan-Feb;6(1):71-5.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

ncbi.nlm.nih.gov/pubmed/26629266
https://pubmed.ncbi.nlm.nih.gov/26413377/
https://www.oursmab.com/News/Vascular-endothelial-growth-factor-receptor-VEGFR2.html

Target Description

Synonyms

kinase insert domain receptor, vascular endothelial growth factor receptor 2, VEGFR2, VEGF-R2, FLK1, CD309

Biology Area

Cancer Biology;Angiogenesis;CD Markers

Function

VEGFR-2, is the primary receptor mediating VEGF-driven angiogenesis. Its activation promotes endothelial cell proliferation, migration, and survival. By inhibiting VEGFR-2, ramucirumab suppresses tumor vascularization and growth, and is often used in combination with chemotherapy in advanced or metastatic settings.

Additional Articles 1

Vascular-endothelial-growth-factor-receptor-VEGFR2

Additional Articles 2

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