Sacituzumab (Biosimilar Reference Antibody) (TACSTD2)
Sacituzumab (Biosimilar Reference Antibody) (TACSTD2)-RA0710-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Sacituzumab (Biosimilar Reference Antibody) (TACSTD2)

Catalog: 

RA0710

Target

TACSTD2/TROP2/EGP1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Sacituzumab is an antibody-drug conjugate (ADC) targeting Trop-2 (trophoblast cell surface antigen 2), a transmembrane glycoprotein overexpressed in many epithelial cancers. It is linked to the cytotoxic payload SN-38 (a topoisomerase I inhibitor). Upon binding to Trop-2, the ADC is internalized, releasing SN-38 to induce DNA damage and tumor cell death. It is approved for the treatment of metastatic triple-negative breast cancer and urothelial carcinoma.

Synonyms

hRS7

CAS

1796566-95-4

Isotype

IgG1 - kappa

Host

Humanised

Target

TACSTD2/TROP2/EGP1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Zhou DD, et al. Elucidating the development, characterization, and antitumor potential of a novel humanized antibody against Trop2[J]. Int J Biol Macromol. 2023 Dec 31;253(Pt 6):127105.

References 2

Sun M, et al. Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2[J]. iScience. 2021 Sep 30;24(10):103190.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/37769779/
https://pubmed.ncbi.nlm.nih.gov/34693228/

Target Description

Synonyms

tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epithelial glycoprotein-1, EGP-1, trophoblast antigen-2, cell surface glycoprotein Trop-2, TROP2

Biology Area

Tumor Antigens;Cancer Biology

Function

Trop-2, is involved in cancer cell proliferation, invasion, and metastasis. Sacituzumab leverages Trop-2 overexpression for targeted delivery of SN-38, enabling potent anti-tumor activity while limiting systemic exposure. Its cleavable linker allows for a "bystander effect," damaging adjacent tumor cells even with heterogeneous Trop-2 expression.

Additional Articles 1

Additional Articles 2

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