Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)
Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)
Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)-RA0787-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)-RA0787 in a linear range of 15.63–125 ng/mL.
Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)

Catalog: 

RA0787

Target

TNFSF13/CD256/APRIL

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Sibeprenlimab (VIS649) is a humanized IgG2 kappa monoclonal antibody targeting a proliferation-inducing ligand (APRIL, TNFSF13). It binds to and neutralizes APRIL, reducing the production of IgA, particularly pathogenic galactose-deficient IgA1 (Gd-IgA1). It is being developed for the treatment of IgA nephropathy (IgAN), aiming to lower levels of nephritogenic antibodies and slow disease progression.

Synonyms

VIS-649

CAS

2382896-07-1

Isotype

IgG2 - kappa

Host

Humanised

Target

TNFSF13/CD256/APRIL

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Mohit Mathur, et al. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VIS649 (Sibeprenlimab), an APRIL-Neutralizing IgG2 Monoclonal Antibody, in Healthy Volunteers. Kidney Int Rep. 2022 Feb 8;7(5):993-1003.

References 2

Mathur M, et al. A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence. J Clin Med. 2023 Nov 4;12(21):6927.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/35570983/
https://pubmed.ncbi.nlm.nih.gov/37959392/
https://www.oursmab.com/News/APRIL-is-a-therapeutic-target-for-IgA-nephropathy.html

Target Description

Synonyms

tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256

Biology Area

Cancer Biology;Stromal Biology;CD Markers

Function

APRIL, is a cytokine crucial for B cell survival, differentiation, and class-switching to IgA. In IgAN, APRIL overexpression drives excessive synthesis of Gd-IgA1, which forms immune complexes that deposit in the kidneys, triggering inflammation and fibrosis. By neutralizing APRIL, sibeprenlimab reduces Gd-IgA1 production, potentially decreasing glomerular injury and preserving renal function.

Additional Articles 1

APRIL-is-a-therapeutic-target-for-IgA-nephropathy

Additional Articles 2

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