Tinurilimab (Biosimilar Reference Antibody) (CEACAM6)
Tinurilimab (Biosimilar Reference Antibody) (CEACAM6)
Tinurilimab (Biosimilar Reference Antibody) (CEACAM6)-RA0140-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tinurilimab (Biosimilar Reference Antibody) (CEACAM6)-RA0140 in a linear range of 15.63–125 ng/mL.
Tinurilimab (Biosimilar Reference Antibody) (CEACAM6)

Catalog: 

RA0140

Target

CEACAM6/CD66c

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size ($):

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tinurilimab is a humanized IgG2 kappa monoclonal antibody targeting carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a glycoprotein overexpressed in many epithelial cancers. It binds to CEACAM6 to block its immunosuppressive function, which normally inhibits effector T cell activity in the tumor microenvironment. It is being developed as an immunomodulatory therapy for CEACAM6-positive solid tumors, such as pancreatic, lung, and colorectal cancers.

Synonyms

BAY-1834942

CAS

2226224-30-0

Isotype

IgG2 - kappa

Host

Humanised

Target

CEACAM6/CD66c

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Pinkert J, et al. T cell-mediated elimination of cancer cells by blocking CEACAM6-CEACAM1 interaction. Oncoimmunology. 2021 Dec 30;11(1):2008110.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/35141051/
https://www.oursmab.com/News/Multifunctional-cell-adhesion-and-signaling-molecule-CEACAM6.html

Target Description

Synonyms

CEA cell adhesion molecule 6

Biology Area

Tumor Antigens;Cancer Biology

Function

CEACAM6, is involved in cell adhesion, metastasis, and immune evasion. It can interact with inhibitory receptors on T cells (e.g., CEACAM1) to dampen anti-tumor responses. Tinurilimab’s blockade of CEACAM6 aims to reverse this suppression, restoring T cell cytotoxicity and promoting tumor clearance.

Additional Articles 1

Multifunctional-cell-adhesion-and-signaling-molecule-CEACAM6

Additional Articles 2

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