Trabikibart (Biosimilar Reference Antibody) (CSF2RB)
Trabikibart (Biosimilar Reference Antibody) (CSF2RB)
Trabikibart (Biosimilar Reference Antibody) (CSF2RB)-RA0160-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Trabikibart (Biosimilar Reference Antibody) (CSF2RB)-RA0160 in a linear range of 15.63–125 ng/mL.
Trabikibart (Biosimilar Reference Antibody) (CSF2RB)

Catalog: 

RA0160

Target

CSF2RB/CD131

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Trabikibart (CSL311) is a fully human IgG4 kappa monoclonal antibody targeting the common beta chain (βc) of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) receptors (also known as CSF2RB). It binds to βc to block signaling by all three cytokines, thereby suppressing inflammation and myeloid cell activation. It is being developed for the treatment of severe asthma, chronic obstructive pulmonary disease (COPD), and other eosinophilic or neutrophilic inflammatory diseases.

Synonyms

CAS

2643974-98-3

Isotype

IgG4 - kappa

Host

Genetically human

Target

CSF2RB/CD131

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Con Panousis, et al. CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors. MAbs. 2016;8(3):436-53.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/26651396/
https://www.oursmab.com/News/Granulocyte-macrophage-colony-stimulating-factor-receptor-CSF2R.html

Target Description

Synonyms

colony stimulating factor 2 (granulocyte-macrophage) receptor beta chain, granulocyte-macrophage colony stimulating factor (GM CSF) receptor beta chain, IL3RB, IL5RB, CD131

Biology Area

Cytokine Receptor;Immunology;CD Markers

Function

βc (CSF2RB), is a shared receptor subunit for GM-CSF, IL-3, and IL-5, cytokines that drive the activation, survival, and recruitment of eosinophils, neutrophils, and macrophages. Trabikibart’s inhibition of βc simultaneously disrupts multiple pro-inflammatory pathways, offering a broad anti-inflammatory effect. This approach aims to reduce airway inflammation, exacerbations, and steroid dependence in respiratory diseases with mixed

Additional Articles 1

Granulocyte-macrophage-colony-stimulating-factor-receptor-CSF2R

Additional Articles 2

Related Products

Bempikibart (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0160

Target：

IL7R/CD127

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Maftivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0160

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Lusvertikimab (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0160

Target：

IL7R/CD127

Isotype：

IgG4 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Odesivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0160

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Porgaviximab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0160

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Enokizumab (Biosimilar Reference Antibody) (IL9)

Catalog: 

RA0160

Target：

IL9

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Bapotulimab (Biosimilar Reference Antibody) (ILDR2)

Catalog: 

RA0160

Target：

ILDR2

Isotype：

IgG2 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Atoltivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0160

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Tocilizumab (Biosimilar Reference Antibody) (IL6R)

Catalog: 

RA0160

Target：

IL6R/CD126

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Cosfroviximab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0160

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus

Contact Us

Send your request

Talk to us 

Get a quotation, discuss your requirement, receive advises from our antibody experts without obligation.