Vixarelimab (Biosimilar Reference Antibody) (OSMR)
Vixarelimab (Biosimilar Reference Antibody) (OSMR)

Catalog: 

RA0539

Target

OSMR

Isotype

IgG4 - lambda2

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Vixarelimab (KPL-716) is an investigational fully human monoclonal antibody that targets the Oncostatin M Receptor β (OSMRβ). It is being developed for the treatment of pruritic (itch-driven) and inflammatory skin conditions, most notably prurigo nodularis and atopic dermatitis, by blocking signaling pathways that drive chronic itch and skin inflammation.

Synonyms

KPL-716

CAS

2243320-83-2

Isotype

IgG4 - lambda2

Host

Genetically human

Target

OSMR

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Carl D Richards, et al. Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716. Acta Derm Venereol. 2020 Jul 2;100(14):adv00197.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32374409/
https://www.oursmab.com/News/The-biligand-shared-receptor-OSMR.html

Target Description

Synonyms

oncostatin M receptor, OSMRB, OSMRbeta

Biology Area

Cytokine Receptor;Immunology

Function

The Oncostatin M Receptor β is a subunit of the functional type II cytokine receptor complexes for both oncostatin M (OSM) and interleukin-31 (IL-31). Signaling through OSMRβ, particularly by IL-31, is a key mediator of pruritus (itch), neuronal hypersensitivity, and skin barrier dysfunction. By inhibiting OSMRβ, vixarelimab aims to disrupt this critical itch and inflammation axis at its root.

Additional Articles 1

The-biligand-shared-receptor-OSMR

Additional Articles 2

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