Epithelial Cell Adhesion Molecule (EpCAM; also known as CD326), a type I transmembrane glycoprotein that is a hallmark of epithelial tissues and carcinomas. EpCAM is a pleiotropic molecule involved in cell adhesion, signaling, proliferation, migration, and stemness. In normal physiology, it plays a role in tissue integrity. In oncology, EpCAM is overexpressed on the majority of epithelial-derived carcinomas (e.g., colorectal, breast, prostate, pancreatic, ovarian cancers) and on cancer stem cells, while its expression in normal epithelial tissues is basolateral and often limited. Its overexpression is associated with poor prognosis.