Afasevikumab (Biosimilar Reference Antibody) (IL17A)
Afasevikumab (Biosimilar Reference Antibody) (IL17A)
Afasevikumab (Biosimilar Reference Antibody) (IL17A)-RA0341-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Afasevikumab (Biosimilar Reference Antibody) (IL17A)-RA0341 in a linear range of 3.91–31.25 ng/mL.
Afasevikumab (Biosimilar Reference Antibody) (IL17A)

Catalog: 

RA0341

Target

IL17A

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Afasevikumab (RG7624, RO5553110) is a fully human monoclonal antibody of the IgG1\kappa isotype. It is a dual inhibitor designed to simultaneously neutralize the activity of both Interleukin-17A (IL-17A) and Interleukin-17F (IL-17F). By binding to these key pro-inflammatory cytokines, Afasevikumab prevents them from initiating the inflammatory cascade associated with various autoimmune and inflammatory disorders. This dual mechanism was hypothesized to offer greater clinical efficacy than targeting IL-17A alone. It was investigated in Phase I clinical trials for the treatment of inflammatory diseases like autoimmune disorders but appears to have been discontinued in development.

Synonyms

MCAF5352A, RO5553110, RG7624, MCAF-5352A, NI-1401, RG-7624

CAS

1589503-30-9

Isotype

IgG1 - kappa

Host

Genetically human

Target

IL17A

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Andrea Chiricozzi, et al. Emerging treatment options for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis: evaluating bimekizumab and its therapeutic potential. Psoriasis (Auckl). 2019 May 24;9:29-35.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/31214486/
https://www.oursmab.com/News/Proinflammatory-cytokine-IL17.html

Target Description

Synonyms

interleukin 17A, IL-17A

Biology Area

Cytokine and Chemokine;Immunology

Function

The targets of Afasevikumab are Interleukin-17A (IL-17A) and Interleukin-17F (IL-17F), two highly homologous cytokines that belong to the IL-17 family. They are primarily secreted by activated T helper 17 (Th17) cells, as well as other innate immune cells like gamma\delta T cells and Natural Killer (NK) cells.

Additional Articles 1

Proinflammatory-cytokine-IL17

Additional Articles 2

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