Alirocumab (Biosimilar Reference Antibody) (PCSK9)
Alirocumab (Biosimilar Reference Antibody) (PCSK9)
Alirocumab (Biosimilar Reference Antibody) (PCSK9)-RA0543-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Alirocumab (Biosimilar Reference Antibody) (PCSK9)-RA0543 in a linear range of 3.91–125 ng/mL.
Alirocumab (Biosimilar Reference Antibody) (PCSK9)

Catalog: 

RA0543

Target

PCSK9

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Alirocumab is a fully human monoclonal antibody (IgG1) designed as a PCSK9 inhibitor for the treatment of hypercholesterolemia. It functions by binding to and inhibiting circulating proprotein convertase subtilisin/kexin type 9, thereby preventing the degradation of hepatic LDL receptors. This leads to a sustained and significant reduction in low-density lipoprotein cholesterol levels. It is administered via subcutaneous injection and is approved for use in patients with atherosclerotic cardiovascular disease (ASCVD) or familial hypercholesterolemia (FH) who require additional LDL-C lowering despite maximally tolerated statin therapy, helping to reduce the risk of heart attack and stroke.

Synonyms

REGN727, SAR-236553, SAR236553

CAS

1245916-14-6

Isotype

IgG1 - kappa

Host

Genetically human

Target

PCSK9

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Markham A. Alirocumab: First Global Approval. Drugs. 2015;75(14):1699-1705.

References 2

Tavori H, et al. Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction. Expert Rev Cardiovasc Ther. 2014 Oct;12(10):1137-44.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/26370210/
https://pubmed.ncbi.nlm.nih.gov/25244623/
https://www.oursmab.com/News/Lipid-control-protein-PCSK9.html

Target Description

Synonyms

proprotein convertase subtilisin/kexin type 9, neural apoptosis-regulated convertase 1, NARC1, NARC-1, proproteine convertase 9, PC9

Biology Area

Metabolism

Function

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), a serine protease primarily synthesized in the liver. Its physiological role is to regulate cholesterol homeostasis

Additional Articles 1

Lipid-control-protein-PCSK9

Additional Articles 2

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