Anti-Human CD274/PDL1/B7H1 Antibody (22C3)
Anti-Human CD274/PDL1/B7H1 Antibody (22C3)-RA0826-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Anti-Human CD274/PDL1/B7H1 Antibody (22C3)

Catalog: 

RA0826

Target

CD274/PDL1/B7H1

Isotype

IgG - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation.

Synonyms

CAS

Isotype

IgG - kappa

Host

Rabbit

Target

CD274/PDL1/B7H1

Reactivity

Human

Expression System

CHO

Applications

ELISA,IF; Recommended dilution: WB:1:5000, IF:1:50-1:200, FC:1:100-1:300

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Pardoll D. Does the immune system see tumors as foreign or self? Annu Rev Immunol. 2003;21:807–839.

References 2

Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med. 2004;10:909–915.

References 3

Rabinovich GA, Gabrilovich D, Sotomayor EM. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol. 2007;25:267–296.

References 4

Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162–174.

References 5

Dave SS, Wright G, Tan B, et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells [see comment]. N Engl J Med. 2004;351:2159–2169.

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/19597183/
https://www.oursmab.com/News/Tumor-escape-switch-PD-1-PD-L1.html

Target Description

Synonyms

programmed cell death 1 ligand 1, B7H1, B7-H1, PDL1, PD-L1, PDCD1L1, B7 homolog 1, B7 homologue 1

Biology Area

Immune Checkpoint;Immunology;Cancer Biology;CD Markers

Function

PD-L1 (CD274), a cell surface glycoprotein frequently overexpressed on tumor cells and antigen-presenting cells within the tumor microenvironment. PD-L1 binds to its receptor, PD-1, on activated T cells, transmitting an inhibitory signal that suppresses T cell proliferation, cytokine production, and cytotoxic function, thereby enabling tumor immune escape.

Additional Articles 1

Tumor-escape-switch-PD-1-PD-L1

Additional Articles 2

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