Anvatabart (Biosimilar Reference Antibody) (ERBB2)
Anvatabart (Biosimilar Reference Antibody) (ERBB2)
Anvatabart (Biosimilar Reference Antibody) (ERBB2)-RA0220-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Anvatabart biosimilar in a linear range of 0.18-31.25 ng/mL.
Anvatabart (Biosimilar Reference Antibody) (ERBB2)

Catalog: 

RA0220

Target

ERBB2/CD340/HER2

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Anvatabart is a clinical-stage, site-specific antibody-drug conjugate (ADC) designed for the treatment of HER2 (ERBB2)-positive solid tumors. It is comprised of a fully human anti-HER2 IgG1κ monoclonal antibody, which is site-specifically conjugated to a proprietary, highly potent microtubule inhibitor payload, AS269. This precise conjugation through non-natural amino acid technology aims to produce a homogeneous ADC with a controlled drug-to-antibody ratio (DAR ≈ 1.8). It is designed to deliver cytotoxic payload directly to HER2-expressing tumor cells with high stability in circulation. It is currently in global Phase II/III clinical trials for metastatic breast cancer and other HER2-positive cancers, representing a next-generation ADC candidate.

Synonyms

ARX788, ARX-788

CAS

2636710-06-8

Isotype

IgG1 - kappa

Host

Humanised

Target

ERBB2/CD340/HER2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Anvatabart

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1339
https://www.oursmab.com/News/Human-epidermal-growth-factor-receptor-HER2.html

Target Description

Synonyms

epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340

Biology Area

Cancer Biology;CD Markers;Tumor Antigens

Function

ERBB2 receptor, more commonly known as Human Epidermal Growth Factor Receptor 2 (HER2). HER2 is a member of the epidermal growth factor receptor (EGFR/ErbB) family of receptor tyrosine kinases. In approximately 15-20% of breast cancers and other solid tumors, the HER2 gene is amplified, leading to protein overexpression on the cancer cell surface. This overexpression drives aggressive tumor growth, proliferation, and survival through constitutive signaling pathways.

Additional Articles 1

Human-epidermal-growth-factor-receptor-HER2

Additional Articles 2

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