Bepranemab (Biosimilar Reference Antibody) (MAPT)
Bepranemab (Biosimilar Reference Antibody) (MAPT)
Bepranemab (Biosimilar Reference Antibody) (MAPT)-RA0475-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Bepranemab (Biosimilar Reference Antibody) (MAPT)-RA0475 in a linear range of 3.91-125 ng/mL.
Bepranemab (Biosimilar Reference Antibody) (MAPT)

Catalog: 

RA0475

Target

MAPT

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Bepranemab is an investigational, humanized monoclonal antibody designed to target Tau protein. It specifically binds to the central region of the Tau protein, aiming to prevent its pathological cell-to-cell propagation and aggregation in the brain. By targeting this region, it is intended to inhibit the spread of Tau pathology, which is a key driver of neurodegeneration in diseases like Alzheimer's disease (AD) and progressive supranuclear palsy (PSP). It is currently in clinical development (Phase II) for the treatment of these Tauopathies.

Synonyms

UCB-0107, UCB0107

CAS

2244960-75-4

Isotype

IgG4 - kappa

Host

Humanised

Target

MAPT

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Matthew E Barton, et al. Design of a patient- and investigator-blind, randomized, placebo-controlled study to evaluate efficacy, safety, and tolerability of bepranemab, UCB0107, in prodromal to mild Alzheimer’s disease: The TOGETHER Study, AH0003. Alzheimer's & Dementia. 31 December 2021.

References 2

Neațu M, et al. Monoclonal Antibody Therapy in Alzheimer's Disease. Pharmaceutics. 2023 Dec 29;16(1):60.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.057586
https://pubmed.ncbi.nlm.nih.gov/38258071/
https://www.oursmab.com/News/The-target-of-Microtubule-Associated-Protein-Tau-MAPT.html

Target Description

Synonyms

microtubule-associated protein tau, tau

Biology Area

Neuroscience

Function

Tau protein, specifically epitopes within its microtubule-binding repeat region in the central part of the protein. Tau is a microtubule-associated protein normally involved in stabilizing neuronal microtubules. In Tauopathies like Alzheimer's and PSP, Tau becomes hyperphosphorylated, misfolds, and aggregates into insoluble intracellular filaments, forming neurofibrillary tangles (NFTs).

Additional Articles 1

The-target-of-Microtubule-Associated-Protein-Tau-MAPT

Additional Articles 2

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