Bexmarilimab (Biosimilar Reference Antibody) (STAB1)
Bexmarilimab (Biosimilar Reference Antibody) (STAB1)
Bexmarilimab (Biosimilar Reference Antibody) (STAB1)-RA0703-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Bexmarilimab (Biosimilar Reference Antibody) (STAB1)-RA0703 in a linear range of 0.18-125 ng/mL.
Bexmarilimab (Biosimilar Reference Antibody) (STAB1)

Catalog: 

RA0703

Target

STAB1

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Bexmarilimab is an investigational, first-in-class bispecific antibody designed as a macrophage-reprogramming immunotherapy. It simultaneously targets two receptors on tumor-associated macrophages (TAMs): Clever-1 (also known as Stabilin-1 or STAB1) and an undisclosed second immune cell receptor (widely reported to be CD40). Its dual mechanism aims to repolarize immunosuppressive “M2-like” TAMs into pro-inflammatory, anti-tumor “M1-like” macrophages and to enhance antigen presentation. It is currently in clinical development (Phase I/II) for the treatment of advanced solid tumors, particularly those with a “cold” tumor microenvironment, such as certain liver and biliary tract cancers.

Synonyms

FP-1302, FP-1305

CAS

2259301-27-2

Isotype

IgG4 - kappa

Host

Humanised

Target

STAB1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Hollmén M, et al. Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers. Mol Cancer Ther. 2022 Jul 5;21(7):1207-1218.

References 2

Elisa M. Vuorinen, et al. Bexmarilimab induces B-cell activation and autoantibody production. Cancer Res 1 April 2023; 83 (7_Supplement): 2269.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/35500016/
https://aacrjournals.org/cancerres/article/83/7_Supplement/2269/719789/Abstract-2269-Bexmarilimab-induces-B-cell
https://www.oursmab.com/News/The-target-of-Stabilin-1-STAB1.html

Target Description

Synonyms

stabilin 1, KIAA0246, STAB-1, FEEL-1, CLEVER-1, FELE-1, FEX1, SCARH2

Biology Area

Immunology;Cancer Biology

Function

Clever-1 (Common lymphatic endothelial and vascular endothelial receptor-1; STAB1), a scavenger receptor highly expressed on a subset of immunosuppressive macrophages and endothelial cells within the tumor microenvironment. Clever-1 is a key mediator of immune tolerance; its engagement suppresses pro-inflammatory cytokine production and T cell activation. The second target (reported to be the co-stimulatory receptor CD40) is expressed on antigen-presenting cells, including macrophages and dendritic cells. CD40 activation provides a potent “license to kill” signal, enhancing antigen presentation and immune activation.

Additional Articles 1

The-target-of-Stabilin-1-STAB1

Additional Articles 2

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