Boserolimab (Biosimilar Reference Antibody) (TNFRSF7)
Boserolimab (Biosimilar Reference Antibody) (TNFRSF7)
Boserolimab (Biosimilar Reference Antibody) (TNFRSF7)-RA0778-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Boserolimab (Biosimilar Reference Antibody) (TNFRSF7)-RA0778 in a linear range of 3.91-125 ng/mL.
Boserolimab (Biosimilar Reference Antibody) (TNFRSF7)

Catalog: 

RA0778

Target

TNFRSF7/CD27

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size ($):

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Boserolimab (also known as MK-5890) is a humanized monoclonal antibody designed to act as an agonistic immune modulator. Its primary function is to specifically target and bind to the CD27 receptor. By engaging CD27, Boserolimab provides a co-stimulatory signal to T cells, mimicking the effect of the natural ligand, CD70. This co-stimulation is intended to enhance T cell mediated immune responses, promoting the proliferation and activation of cytotoxic T lymphocytes (CTLs). This mechanism makes it a candidate for cancer immunotherapy, where the goal is to boost the body's immune attack against malignant cells.

Synonyms

MK-5890, MK5890

CAS

2444297-08-7

Isotype

IgG1 - kappa

Host

Chimeric Humanized

Target

TNFRSF7/CD27

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

IMGT

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1308

Target Description

Synonyms

TNFRSF7, tumor necrosis factor receptor (TNFR) superfamily member 7

Biology Area

Immunology;Immune Checkpoint

Function

CD27 receptor, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily, also known as TNFRSF7. CD27 is a crucial co-stimulatory molecule predominantly expressed on the surface of most mature T cells, as well as on B cells and Natural Killer (NK) cells.

Additional Articles 1

Additional Articles 2

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