Briquilimab (Biosimilar Reference Antibody) (KIT)
Briquilimab (Biosimilar Reference Antibody) (KIT)
Briquilimab (Biosimilar Reference Antibody) (KIT)-RA0444-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Briquilimab (Biosimilar Reference Antibody) (KIT)-RA0444 in a linear range of 01.8-125 ng/mL.
Briquilimab (Biosimilar Reference Antibody) (KIT)

Catalog: 

RA0444

Target

KIT/CD117

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Briquilimab (formerly known as JSP191) is a monoclonal antibody in clinical development as a conditioning agent for stem cell transplants and gene therapies. It works by selectively depleting blood-forming stem cells in the bone marrow to create space for new, healthy donor or gene-corrected stem cells to engraft. Unlike traditional chemotherapy- or radiation-based conditioning, Briquilimab is designed to be more targeted. It achieved an important milestone by being granted Breakthrough Therapy Designation by the U.S. FDA in 2023 for use in patients with severe combined immunodeficiency (SCID) undergoing stem cell transplantation.

Synonyms

JSP191, AMG 191, AMG-191, AMG191

CAS

2574591-89-0

Isotype

IgG1 - kappa

Host

Chimeric

Target

KIT/CD117

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Rajni Agarwal, et al., First Report of Non-Genotoxic Conditioning with JSP191 (anti-CD117) and Hematopoietic Stem Cell Transplantation in a Newly Diagnosed Patient with Severe Combined Immune Deficiency, Blood, Volume 136, Supplement 1, 2020, Page 10, ISSN 0006-4971.

References 2

Dawoon Jung, et al., Pharmacokinetics of Briquilimab as a Conditioning Agent for Hematopoietic Stem Cell Transplantation in Patients With Severe Combined Immunodeficiency, Myelodysplastic Syndrome, or Acute Myeloid Leukemia, Transplantation and Cellular Therapy, Volume 30, Issue 9, 2024, Pages 923.e1-923.e9, ISSN 2666-6367

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.sciencedirect.com/science/article/pii/S0006497118706733
https://www.sciencedirect.com/science/article/pii/S2666636724004949
https://www.oursmab.com/News/The-stem-cell-factor-receptor-CD117.html

Target Description

Synonyms

KIT proto-oncogene receptor tyrosine kinase, C-Kit, c-kit, SCFR, CD117

Biology Area

Cancer Biology;CD Markers

Function

The c-Kit receptor (CD117), which is highly expressed on the surface of hematopoietic stem and progenitor cells (HSPCs).

Additional Articles 1

The-stem-cell-factor-receptor-CD117

Additional Articles 2

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