SLC29A2 is a widely expressed nucleoside transporter, primarily responsible for the cellular uptake of nucleosides and nucleobases. By regulating the availability of these critical precursors, it plays a key role in DNA/RNA synthesis, salvage pathways for nucleotide production, and the cellular uptake of numerous nucleoside analog drugs (e.g., fludarabine, gemcitabine). Its transport activity is essential for normal cell physiology and significantly influences the pharmacokinetics and efficacy of anticancer and antiviral therapies.