Depemokimab (Biosimilar Reference Antibody) (IL5)
Depemokimab (Biosimilar Reference Antibody) (IL5)
Depemokimab (Biosimilar Reference Antibody) (IL5)-RA0394-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Depemokimab (Biosimilar Reference Antibody) (IL5)-RA0394 in a linear range of 3.91-125 ng/mL.
Depemokimab (Biosimilar Reference Antibody) (IL5)

Catalog: 

RA0394

Target

IL5

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Depemokimab is an experimental biologic drug that targets Interleukin-5 (IL-5) to treat severe asthma with type 2 inflammation and chronic rhinosinusitis with nasal polyps (CRSwNP). It is an ultra-long-acting therapy designed for twice-yearly, or every six-month, injections. Clinical trials have shown depemokimab can significantly reduce asthma attacks and CRSwNP symptoms.

Synonyms

GSK-3511294

CAS

2243274-14-6

Isotype

IgG1 - kappa

Host

Humanised

Target

IL5

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Calzetta L, et al. Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma. Biomedicines. 2022 Sep 19;10(9):2330.

References 2

Singh D, et al. A Phase 1 study of the long-acting anti-IL-5 monoclonal antibody GSK3511294 in patients with asthma. Br J Clin Pharmacol. 2022 Feb;88(2):702-712.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/36140430/
https://pubmed.ncbi.nlm.nih.gov/34292606/
https://www.oursmab.com/News/eosinophilic-inflammatory-factor-IL5.html

Target Description

Synonyms

interleukin 5, IL-5

Biology Area

Cytokine and Chemokine;Immunology

Function

Interleukin-5 (IL-5), a cytokine produced predominantly by type 2 helper T cells (Th2) and group 2 innate lymphoid cells (ILC2s). IL-5 is the principal regulator of eosinophil biology. It binds to the IL-5 receptor (IL-5Rα/βc) on eosinophil precursors in the bone marrow, promoting their proliferation, differentiation, and release into circulation. It also enhances eosinophil activation, tissue migration, and survival at sites of inflammation.

Additional Articles 1

eosinophilic-inflammatory-factor-IL5

Additional Articles 2

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