Dezamizumab (Biosimilar Reference Antibody) (APCS)
Dezamizumab (Biosimilar Reference Antibody) (APCS)
Dezamizumab (Biosimilar Reference Antibody) (APCS)-RA0018-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Dezamizumab (Biosimilar Reference Antibody) (APCS)-RA0018 in a linear range of 3.91-125 ng/mL.
Dezamizumab (Biosimilar Reference Antibody) (APCS)

Catalog: 

RA0018

Target

APCS/SAP

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Dezamizumab (GSK 2398852) is a fully humanized recombinant monoclonal IgG1 antibody specifically targeting the serum amyloid P component (SAP). It was developed as a potential therapy for systemic amyloidosis, a group of diseases characterized by the deposition of misfolded protein fibrils (amyloid) in organs and tissues. The antibody's mechanism was designed to bind to SAP, a universal constituent of amyloid deposits, and promote their clearance by the immune system. Despite reaching clinical trials, the development of dezamizumab for amyloidosis was ultimately discontinued due to an unfavorable benefit-risk assessment, including insufficient efficacy in clearing amyloid from critical organs like the heart.

Synonyms

GSK-2398852, GSK2398852

CAS

1662664-56-3

Isotype

IgG1 - kappa

Host

Humanised

Target

APCS/SAP

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Parrondo RD, et, al. Antibody-based immunotherapy for treatment of immunoglobulin light-chain amyloidosis. Br J Haematol. 2020 Dec;191(5):673-681.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32298469/
https://www.oursmab.com/News/Calcium-dependent-agglutinin-APCS.html

Target Description

Synonyms

amyloid P component, serum, "9.5S alpha-1-glycoprotein", MGC88159, "pentraxin-2", "pentraxin-related", PTX2, SAP

Biology Area

Immunology;Metabolism

Function

Serum amyloid P component (SAP), a pentameric plasma protein of the pentraxin family that circulates in the blood and also binds calcium-dependently to all types of amyloid fibrils. SAP is thought to stabilize amyloid deposits by protecting them from degradation, thereby contributing to disease progression.

Additional Articles 1

Calcium-dependent-agglutinin-APCS

Additional Articles 2

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