Dusigitumab (Biosimilar Reference Antibody) (IGF1 and IGF2)
Dusigitumab (Biosimilar Reference Antibody) (IGF1 and IGF2)
Dusigitumab (Biosimilar Reference Antibody) (IGF1 and IGF2)-RA0314-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Dusigitumab (Biosimilar Reference Antibody) (IGF1 and IGF2)-RA0314 in a linear range of 15.63-500 ng/mL.
Dusigitumab (Biosimilar Reference Antibody) (IGF1 and IGF2)

Catalog: 

RA0314

Target

IGF1 and IGF2

Isotype

IgG2 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Dusigitumab (MEDI 573) is a human IgG2λ monoclonal antibody developed as a targeted therapy for cancer. It is designed to neutralize the insulin-like growth factor (IGF) pathway by specifically binding to and inhibiting both IGF2 (Insulin-like Growth Factor 2) and IGF1 (Insulin-like Growth Factor 1). This dual-neutralization aims to block the activation of the IGF-1 receptor (IGF-1R) signaling axis, a key driver of tumor growth, survival, and resistance to therapy in various solid tumors. Clinical trials have evaluated its potential in malignancies where the IGF pathway is implicated, such as hepatocellular carcinoma and other advanced solid tumors.

Synonyms

MEDI-573

CAS

1204390-13-5

Isotype

IgG2 - lambda

Host

Genetically human

Target

IGF1 and IGF2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Dusigitumab. IMGT.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/result.action

Target Description

Synonyms

insulin-like growth factor 2, somatomedin A, insulin-like growth factor 1, somatomedin C

Biology Area

Cancer Biology;Metabolism

Function

IGF2 and IGF1, two peptide hormones that primarily signal through the IGF-1 receptor (IGF-1R). The IGF pathway plays a crucial role in normal growth and metabolism, but it is frequently dysregulated in cancer. Overexpression of IGF ligands, especially IGF2 (often due to loss of imprinting), and activation of IGF-1R promote tumor cell proliferation, inhibit apoptosis, and contribute to treatment resistance.

Additional Articles 1

Additional Articles 2

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