Eldelumab (Biosimilar Reference Antibody) (CXCL10)
Eldelumab (Biosimilar Reference Antibody) (CXCL10)
Eldelumab (Biosimilar Reference Antibody) (CXCL10)-RA0180-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Eldelumab (Biosimilar Reference Antibody) (CXCL10)-RA0180 in a linear range of 3.91-125 ng/mL.
Eldelumab (Biosimilar Reference Antibody) (CXCL10)

Catalog: 

RA0180

Target

CXCL10/IP10

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Eldelumab (development code BMS-936557) is an investigational, fully human monoclonal antibody developed as a targeted anti-inflammatory therapy. It functions as a specific chemokine inhibitor. Its primary mechanism of action is to directly bind and neutralize its target chemokine in the extracellular space, thereby blocking the target-induced calcium flux and chemotactic cell migration that are critical steps in the recruitment of inflammatory immune cells to sites of tissue damage or inflammation.

Synonyms

BMS-936557, MDX-1100

CAS

946414-98-8

Isotype

IgG1 - kappa

Host

Genetically human

Target

CXCL10/IP10

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Gupta RK, et al. Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium. PLoS One. 2021 Sep 28;16(9):e0257784.

References 2

Asquith DL, et al. Targeting cell migration in rheumatoid arthritis. Curr Opin Rheumatol. 2015 Mar;27(2):204-11.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34582497/
https://pubmed.ncbi.nlm.nih.gov/25603038/
https://www.oursmab.com/News/The-chemokine-CXCL10.html

Target Description

Synonyms

chemokine C-X-C motif ligand 10, 10 kDa interferon gamma-induced protein gamma-IP10, IP-10, INP10, small inducible cytokine B10, SCYB10

Biology Area

Cytokine and Chemokine;Immunology

Function

CXCL10, also known as Interferon-gamma-induced protein 10 kDa (IP-10). CXCL10 is a C-X-C motif chemokine that is powerfully induced by interferon-gamma (IFN-γ) and other pro-inflammatory signals. Its primary biological function is to bind to and signal through the CXCR3 receptor, which is expressed on activated T cells (particularly Th1 cells), NK cells, and other leukocytes. By binding to CXCR3, CXCL10 triggers intracellular calcium flux and directs the migration (chemotaxis) of these effector cells toward sites of high chemokine concentration, such as inflamed tissues in autoimmune diseases, chronic viral infections, and allograft rejection.

Additional Articles 1

The-chemokine-CXCL10

Additional Articles 2

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