Elotuzumab (Biosimilar Reference Antibody) (SLAMF7)
Elotuzumab (Biosimilar Reference Antibody) (SLAMF7)
Elotuzumab (Biosimilar Reference Antibody) (SLAMF7)-RA0688-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Elotuzumab (Biosimilar Reference Antibody) (SLAMF7)-RA0688 in a linear range of 0.18-500 ng/mL.
Elotuzumab (Biosimilar Reference Antibody) (SLAMF7)

Catalog: 

RA0688

Target

SLAMF7/CD319

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Elotuzumab is a humanized immunoglobulin G1 (IgG1) monoclonal antibody approved for the treatment of multiple myeloma. It represents a first-in-class immunostimulatory therapy with a unique dual mechanism of action. First, it directly binds to SLAMF7 on myeloma cells. Second, and critically, it simultaneously binds to Fc gamma receptors (FcγR) on natural killer (NK) cells via its Fc portion. This dual engagement specifically activates NK cells and directs their cytotoxic activity against the SLAMF7-positive myeloma cells, primarily through antibody-dependent cellular cytotoxicity (ADCC). Unlike most monoclonal antibodies, elotuzumab does not directly induce apoptosis or block a signaling pathway on the tumor cell itself.

Synonyms

BMS-901608, HuLuc63, PDL-063, PDL063

CAS

915296-00-3

Isotype

IgG1 - kappa

Host

Humanised

Target

SLAMF7/CD319

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Magen H, et al. Elotuzumab: the first approved monoclonal antibody for multiple myeloma treatment. Ther Adv Hematol. 2016;7(4):187-195.

References 2

Bezman NA, et al. PD-1 blockade enhances elotuzumab efficacy in mouse tumor models. Blood Adv. 2017 May 8;1(12):753-765.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pmc.ncbi.nlm.nih.gov/articles/PMC4959642/
https://pubmed.ncbi.nlm.nih.gov/29296719/

Target Description

Synonyms

SLAM family member 7, CD2 subset 1, CS1, CD2-like receptor-activating cytotoxic cells, CRACC, 19A24, CD319

Biology Area

Immunology;CD Markers;Cancer Biology

Function

Signaling Lymphocytic Activation Molecule Family member 7 (SLAMF7), also known as CS1 or CD319. SLAMF7 is a cell surface glycoprotein that is highly and uniformly expressed on multiple myeloma cells and plasma cells, with relatively restricted expression on normal tissues (mainly NK cells and a subset of other immune cells). In normal NK cell biology, SLAMF7 acts as a self-ligand that provides a costimulatory activation signal. In multiple myeloma, its high expression is associated with tumor cell adhesion, survival, and interaction with the bone marrow microenvironment.

Additional Articles 1

Additional Articles 2

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