Enoblituzumab (Biosimilar Reference Antibody) (CD276)
Enoblituzumab (Biosimilar Reference Antibody) (CD276)
Enoblituzumab (Biosimilar Reference Antibody) (CD276)-RA0082-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Enoblituzumab (Biosimilar Reference Antibody) (CD276)-RA0082 in a linear range of 3.91-125 ng/mL.
Enoblituzumab (Biosimilar Reference Antibody) (CD276)

Catalog: 

RA0082

Target

CD276

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Enoblituzumab (development code MGA271) is an investigational, humanized Fc-engineered monoclonal IgG1 antibody developed for the treatment of solid tumors. Its design incorporates a modified Fc domain to enhance immune activation. Enoblituzumab functions as a targeted immunotherapeutic agent by binding to a specific antigen highly expressed on a variety of cancer cells. The antibody's primary anti-tumor mechanism is believed to be antibody-dependent cellular cytotoxicity (ADCC), where its optimized Fc region potently engages natural killer (NK) cells and other immune effector cells to kill the bound tumor cells. It may also inhibit pro-tumorigenic signaling pathways within the cancer cell.

Synonyms

MGA271, MG-A271

CAS

1353485-38-7

Isotype

IgG1 - kappa

Host

Humanised

Target

CD276

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Hińcza-Nowak K, et al. Immune Profiling of Medullary Thyroid Cancer-An Opportunity for Immunotherapy. Genes (Basel). 2021 Sep 28;12(10):1534.

References 2

Chapoval, et al. Immune Checkpoints of the B7 Family. Part 2. Representatives of the B7 Family B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, and ILDR2 and Their Receptors. Russ J Bioorg Chem 45, 321–334 (2019).

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34680929/
https://link.springer.com/article/10.1134/S1068162019050091#citeas
https://www.oursmab.com/News/The-immune-checkpoint-molecule-B7H3.html

Target Description

Synonyms

B7H3, B7-H3, B7-related protein 2, B7RP2, B7RP-2, B7 homolog 3, B7 homologue 3

Biology Area

Immune Checkpoint;Immunology;Cancer Biology

Function

B7-H3, also known as CD276. B7-H3 is a type I transmembrane protein belonging to the B7 family of immune checkpoint molecules. Unlike its relatives PD-L1 (B7-H1) or B7-H4, B7-H3's exact receptor on T cells and its precise role in immune regulation remain less clearly defined. However, it is broadly and highly overexpressed on a wide range of solid tumors—including prostate cancer, melanoma, non-small cell lung cancer, and glioblastoma—while showing limited expression in most normal tissues.

Additional Articles 1

The-immune-checkpoint-molecule-B7H3

Additional Articles 2

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