Ensituximab (Biosimilar Reference Antibody) (MUC5AC)
Ensituximab (Biosimilar Reference Antibody) (MUC5AC)-RA0518-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Ensituximab (Biosimilar Reference Antibody) (MUC5AC)

Catalog: 

RA0518

Target

MUC5AC

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Ensituximab (also known as NEO-102 and NPC-1C) is a novel, chimeric immunoglobulin G1 (IgG1) monoclonal antibody developed as a biological therapy for patients with pancreatic and colorectal cancers. It was designed to bind to a set of human colorectal and pancreatic carcinoma-associated antigens. The exact molecular target(s) of ensituximab remain(s) uncertain, representing a unique and challenging aspect of its development. While initially described as targeting undefined tumor-associated antigens, subsequent research suggested that its primary target might be the specific mucin protein MUC5AC. The intended mechanism of action involves binding to these antigens on the surface of cancer cells, potentially inhibiting tumor-promoting functions and marking the cells for immune-mediated destruction (e.g., via ADCC).

Synonyms

NPC-1C, NOE-102

CAS

1092658-06-4

Isotype

IgG1 - kappa

Host

Chimeric

Target

MUC5AC

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Richard D Kim, et al. Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer. Clin Cancer Res. 2020 Jul 15;26(14):3557-3564.

References 2

Julian A Marin-Acevedo, et al. Cancer immunotherapy beyond immune checkpoint inhibitors. J Hematol Oncol. 2018 Jan 12;11(1):8.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32303539/
https://pubmed.ncbi.nlm.nih.gov/29329556/
https://www.oursmab.com/News/Gastric-mucin-MUC5A.html

Target Description

Synonyms

mucin 5AC, mucin 5 subtypes A and C tracheobronchial/gastric

Biology Area

Immunology;Cancer Biology

Function

Mucin 5AC (MUC5AC), a high-molecular-weight, gel-forming glycoprotein. MUC5AC is a member of the mucin family and is normally expressed in the respiratory tract, stomach, and endocervix. However, it is also aberrantly and highly expressed in a significant subset of pancreatic ductal adenocarcinomas (PDAC) and colorectal cancers (CRC), where its expression is often associated with more aggressive disease and poorer prognosis. In cancer, mucins like MUC5AC can promote tumor progression by modulating cell adhesion, signaling, metastasis, and immune evasion.

Additional Articles 1

Gastric-mucin-MUC5A

Additional Articles 2

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