Eurestobart (Biosimilar Reference Antibody) (ENTPD1)
Eurestobart (Biosimilar Reference Antibody) (ENTPD1)-RA0212-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Eurestobart (Biosimilar Reference Antibody) (ENTPD1)

Catalog: 

RA0212

Target

ENTPD1/CD39

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size ($):

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Eurestobart is an investigational, humanized immunoglobulin G1 kappa (IgG1κ) monoclonal antibody being developed for potential applications in oncology and immunomodulation. It functions as a targeted inhibitor of ectonucleoside triphosphate diphosphohydrolase activity, specifically by binding to a member of the ENTPDase family (also known as CD39 family). By binding to its target ENTPDase, this antibody is designed to modulate the extracellular purinergic signaling pathway. This modulation primarily affects the conversion of pro-inflammatory extracellular ATP (eATP) into immunosuppressive adenosine, thereby aiming to shift the balance in the tumor microenvironment or inflammatory sites from an immunosuppressive state towards a more immunostimulatory one.

Synonyms

CAS

2682847-53-4

Isotype

IgG1 - kappa

Host

Humanised

Target

ENTPD1/CD39

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

IMGT

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1400
https://www.oursmab.com/News/The-immunosuppressive-enzyme-CD39.html

Target Description

Synonyms

ectonucleoside triphosphate diphosphohydrolase 1,, NTPDase-1, ATPDase, SPG64, CD39

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

Ectonucleoside Triphosphate Diphosphohydrolase, most commonly CD39 (ENTPD1). CD39 is a cell surface ectoenzyme that catalyzes the first and rate-limiting step in the hydrolysis of extracellular ATP (eATP) and ADP to AMP. AMP is then rapidly converted to immunosuppressive adenosine by another ectoenzyme, CD73 (ecto-5'-nucleotidase).

Additional Articles 1

The-immunosuppressive-enzyme-CD39

Additional Articles 2

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