Ifinatamab (Biosimilar Reference Antibody) (CD276)
Ifinatamab (Biosimilar Reference Antibody) (CD276)
Ifinatamab (Biosimilar Reference Antibody) (CD276)-RA0083-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Ifinatamab (Biosimilar Reference Antibody) (CD276)-RA0083 in a linear range of 3.91–31 ng/mL.
Ifinatamab (Biosimilar Reference Antibody) (CD276)

Catalog: 

RA0083

Target

CD276

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Ifinatamab deruxtecan (I-DXd) is an investigational antibody-drug conjugate (ADC) targeting the B7-H3 protein, used in advanced cancers like small cell lung cancer (SCLC) and prostate cancer, showing promising response rates in Phase 2 trials, though it carries risks like fatigue, low blood counts, and lung issues, and is under development by Daiichi Sankyo & Merck.

Synonyms

MABX-9001a

CAS

2484870-90-6

Isotype

IgG1 - kappa

Host

Humanised

Target

CD276

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

WHO Drug Information. International Nonproprietary Names for Pharmaceutical.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.who.int/our-work/access-to-medicines-and-health-products/who-drug-information
https://www.oursmab.com/News/The-immune-checkpoint-molecule-B7H3.html

Target Description

Synonyms

B7H3, B7-H3, B7-related protein 2, B7RP2, B7RP-2, B7 homolog 3, B7 homologue 3

Biology Area

Immune Checkpoint;Immunology;Cancer Biology

Function

B7-H3, also known as CD276. B7-H3 is a type I transmembrane protein belonging to the B7 family of immune checkpoint molecules. Unlike its relatives PD-L1 (B7-H1) or B7-H4, B7-H3's exact receptor on T cells and its precise role in immune regulation remain less clearly defined. However, it is broadly and highly overexpressed on a wide range of solid tumors—including prostate cancer, melanoma, non-small cell lung cancer, and glioblastoma—while showing limited expression in most normal tissues.

Additional Articles 1

The-immune-checkpoint-molecule-B7H3

Additional Articles 2

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