Itolizumab (Biosimilar Reference Antibody) (CD6)
Itolizumab (Biosimilar Reference Antibody) (CD6)
Itolizumab (Biosimilar Reference Antibody) (CD6)-RA0127-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Itolizumab (Biosimilar Reference Antibody) (CD6)-RA0127 in a linear range of 15.63–125 ng/mL.
Itolizumab (Biosimilar Reference Antibody) (CD6)

Catalog: 

RA0127

Target

CD6

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Itolizumab is a humanized, recombinant monoclonal antibody that uniquely targets the CD6 receptor on T cells. It functions as an immune modulator by binding to the SRCR-1 domain of CD6, thereby interfering with the CD6-ALCAM (Activated Leukocyte Cell Adhesion Molecule) interaction. This action inhibits T-cell activation, proliferation, and migration to inflammatory sites. Itolizumab is notable for being one of the first anti-CD6 antibodies approved for therapeutic use, specifically in India for moderate to severe chronic plaque psoriasis. It is also being investigated for other autoimmune conditions and cytokine storm-associated complications, such as in severe COVID-19.

Synonyms

T1h

CAS

1116433-11-4

Isotype

IgG1 - kappa

Host

Humanised

Target

CD6

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Saavedra D, et al. An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients. Immun Ageing. 2020 Nov 14;17(1):34.

References 2

Loganathan S, et al. Itolizumab, an anti-CD6 monoclonal antibody, as a potential treatment for COVID-19 complications. Expert Opin Biol Ther. 2020 Sep;20(9):1025-1031.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/33292350/
https://pubmed.ncbi.nlm.nih.gov/32700604/
https://www.oursmab.com/News/Lymphocyte-activation-targets-CD6.html

Target Description

Synonyms

Tp120, T12

Biology Area

Immunology;CD Markers

Function

CD6 is a type I transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. It is predominantly expressed on the surface of mature T cells and a subset of B cells. CD6 acts as a co-stimulatory receptor, with its primary ligand being ALCAM (CD166), which is expressed on antigen-presenting cells (APCs) and various epithelial/endothelial cells.

Additional Articles 1

Lymphocyte-activation-targets-CD6

Additional Articles 2

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