Lacnotuzumab (Biosimilar Reference Antibody) (CSF1)
Lacnotuzumab (Biosimilar Reference Antibody) (CSF1)
Lacnotuzumab (Biosimilar Reference Antibody) (CSF1)-RA0150-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Lacnotuzumab (Biosimilar Reference Antibody) (CSF1)-RA0150 in a linear range of 0.18–15 ng/mL.
Lacnotuzumab (Biosimilar Reference Antibody) (CSF1)

Catalog: 

RA0150

Target

CSF1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Lacnotuzumab (also known as MCS110) is a human monoclonal antibody that targets colony-stimulating factor 1 (CSF-1 or M-CSF). It functions by binding to and neutralizing circulating CSF-1, thereby inhibiting its interaction with the CSF-1 receptor (CSF-1R) on target cells. This blockade aims to deplete tumor-associated macrophages (TAMs), particularly the pro-tumorigenic M2 phenotype, within the tumor microenvironment. By modulating the immune landscape, Lacnotuzumab seeks to enhance anti-tumor immunity and has been investigated in clinical trials for the treatment of various solid tumors, such as tenosynovial giant cell tumor (TGCT) and certain advanced cancers, often in combination with other therapies.

Synonyms

MCS110, MCS-110

CAS

1831128-32-5

Isotype

IgG1 - kappa

Host

Humanised

Target

CSF1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Kuemmel S, et, al. A Randomized Phase II Study of Anti-CSF1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple-Negative Breast Cancer. Clin Cancer Res. 2022 Jan 1;28(1):106-115.

References 2

Pognan F, et, al. Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34615719/
https://pubmed.ncbi.nlm.nih.gov/30894455/
https://www.oursmab.com/News/The-target-of-Macrophage-colony-stimulating-factor-1-CSF1.html

Target Description

Synonyms

colony stimulating factor 1, "colony stimulating factor 1 (macrophage)", M-CSF, macrophage colony stimulating factor 1, MCSF, MGC31930

Biology Area

Immunology;Cancer Biology

Function

Colony-Stimulating Factor 1 (CSF-1 or Macrophage Colony-Stimulating Factor, M-CSF) is a hematopoietic cytokine that is essential for the survival, proliferation, differentiation, and function of monocytes and macrophages. It exerts its effects by binding to and activating the CSF-1 receptor (CSF-1R), a receptor tyrosine kinase expressed on myeloid lineage cells. In cancer, tumor-derived CSF-1 recruits and polarizes macrophages toward an M2-like, pro-tumorigenic phenotype (TAMs).

Additional Articles 1

The-target-of-Macrophage-colony-stimulating-factor-1-CSF1

Additional Articles 2

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