Lampalizumab (Biosimilar Reference Antibody) (CFD)
Lampalizumab (Biosimilar Reference Antibody) (CFD)

Catalog: 

RA0141

Target

CFD

Isotype

Fab - G1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Lampalizumab (also known as RG-7417) was an investigational, humanized monoclonal antibody fragment (Fab) designed to target complement factor D (CFD). It was developed as a potential therapy for geographic atrophy (GA), the advanced, atrophic form of age-related macular degeneration (AMD). By specifically inhibiting factor D, a rate-limiting enzyme in the alternative complement pathway, Lampalizumab aimed to reduce chronic inflammation and complement-mediated damage to retinal cells. Despite promising early and mid-stage clinical results, it did not meet its primary efficacy endpoints in Phase III trials (CHROMA and SPECTRI) and its development for GA was discontinued.

Synonyms

AFD, Anti-fD, Anti-FACTOR D, FCFD4514S, RG7417

CAS

1278466-20-8

Isotype

Fab - G1 - kappa

Host

Humanised

Target

CFD

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475.

References 2

Hanus J, et al. Current therapeutic developments in atrophic age-related macular degeneration. Br J Ophthalmol. 2016 Jan;100(1):122-7.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/27810992/
https://pubmed.ncbi.nlm.nih.gov/26553922/
https://www.oursmab.com/News/Complement-alternative-pathway-rate-limiting-enzyme-CFD .html

Target Description

Synonyms

complement factor D, C3 convertase activator, properdin factor D, adipsin

Biology Area

Immunology;Innate Immunity;Ophthalmology

Function

Complement Factor D is a serine protease that plays a critical and rate-limiting role in the alternative complement pathway. It circulates in the blood in its active form and is responsible for cleaving factor B when the latter is bound to activated complement component C3b. This cleavage is an essential step in the formation of the C3 convertase (C3bBb), which amplifies the complement cascade, leading to opsonization, inflammation, and cell lysis.

Additional Articles 1

Complement-alternative-pathway-rate-limiting-enzyme-CFD

Additional Articles 2

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