Lenzilumab (Biosimilar Reference Antibody) (CSF2)
Lenzilumab (Biosimilar Reference Antibody) (CSF2)
Lenzilumab (Biosimilar Reference Antibody) (CSF2)-RA0155-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Lenzilumab (Biosimilar Reference Antibody) (CSF2)-RA0155 in a linear range of 3.91–31 ng/mL.
Lenzilumab (Biosimilar Reference Antibody) (CSF2)

Catalog: 

RA0155

Target

CSF2

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Lenzilumab is a fully human monoclonal antibody that selectively targets and neutralizes granulocyte-macrophage colony-stimulating factor (GM-CSF), a pro-inflammatory cytokine. By binding to GM-CSF, it prevents the cytokine from interacting with its receptor (GM-CSFR) on immune cells, thereby inhibiting the downstream signaling cascade that drives hyperinflammation and cytokine release syndrome (CRS). It has been investigated as a therapeutic agent for conditions characterized by excessive immune activation, most notably in hospitalized patients with COVID-19 pneumonia to prevent or mitigate severe respiratory complications. It is also being explored in other hyperinflammatory and autoimmune contexts, such as acute graft-versus-host disease (aGVHD).

Synonyms

KB-003, KB003

CAS

1229575-09-0

Isotype

IgG1 - kappa

Host

Genetically human

Target

CSF2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Rosalie M Sterner, et al. GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts. Blood. 2019 Feb 14;133(7):697-709.

References 2

Zelalem Temesgen, et al. GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia: A Case-Cohort Study. Mayo Clin Proc. 2020 Nov;95(11):2382-2394.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/30463995/
https://pubmed.ncbi.nlm.nih.gov/33153629/
https://www.oursmab.com/News/Granulocyte-macrophage-stimulating-factor-CSF2.html

Target Description

Synonyms

colony stimulating factor 2 (granulocyte-macrophage), granulocyte-macrophage colony stimulating factor, GM-CSF

Biology Area

Cytokine and Chemokine;Immunology

Function

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor and pro-inflammatory cytokine produced by various cells, including T cells, macrophages, and epithelial cells. It signals through a receptor complex (GM-CSFR) expressed on myeloid lineage cells (e.g., neutrophils, monocytes, macrophages, dendritic cells). GM-CSF plays a key role in the maturation, activation, and survival of these cells.

Additional Articles 1

Granulocyte-macrophage-stimulating-factor-CSF2

Additional Articles 2

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