Leronlimab (Biosimilar Reference Antibody) (CCR5)
Leronlimab (Biosimilar Reference Antibody) (CCR5)-RA0066-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Leronlimab (Biosimilar Reference Antibody) (CCR5)

Catalog: 

RA0066

Target

CCR5/CD195

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Leronlimab (also known as PRO 140) is a humanized IgG4 monoclonal antibody that functions as a CCR5 antagonist. It selectively binds to the CCR5 chemokine receptor on the surface of CD4+ T cells and other immune cells, blocking its interaction with natural ligands and, most critically, with the human immunodeficiency virus (HIV-1) envelope glycoprotein gp120. This blockade prevents the viral entry step that is dependent on the CCR5 co-receptor. It has been developed as a long-acting (weekly subcutaneous) antiretroviral therapy for CCR5-tropic HIV-1 infection, showing efficacy in treatment-experienced patients. It has also been investigated for other conditions where CCR5 plays a role, such as metastatic cancer and COVID-19, though clinical benefit in these areas remains unconfirmed.

Synonyms

PRO 140, HuPRO-140, PRO-140

CAS

674782-26-4

Isotype

IgG4 - kappa

Host

Humanised

Target

CCR5/CD195

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Jiao X, et al. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Breast Cancer Res. 2021 Jan 23;23(1):11.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/33485378/
https://www.oursmab.com/News/HIV-invades-the-coreceptor-CCR5.html

Target Description

Synonyms

chemokine (C-C motif) receptor 5, CD195

Biology Area

Immunology;Cytokine Receptor;CD Markers

Function

CCR5 (C-C chemokine receptor type 5) is a G protein-coupled receptor (GPCR) expressed on the surface of various immune cells, including T cells, macrophages, and dendritic cells. Its physiological role involves mediating cell migration in response to chemokines (e.g., RANTES/CCL5, MIP-1α/CCL3, MIP-1β/CCL4). In HIV-1 pathogenesis, CCR5 serves as the primary co-receptor (alongside CD4) for the entry of the most common strains (R5-tropic) of HIV-1 into host cells.

Additional Articles 1

HIV-invades-the-coreceptor-CCR5

Additional Articles 2

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