Lexatumumab (Biosimilar Reference Antibody) (TNFRSF10B)
Lexatumumab (Biosimilar Reference Antibody) (TNFRSF10B)
Lexatumumab (Biosimilar Reference Antibody) (TNFRSF10B)-RA0752-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Lexatumumab (Biosimilar Reference Antibody) (TNFRSF10B)-RA0752 in a linear range of 3.91–31 ng/mL.
Lexatumumab (Biosimilar Reference Antibody) (TNFRSF10B)

Catalog: 

RA0752

Target

TNFRSF10B/CD262/DR5/TRAILR2

Isotype

IgG1 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Lexatumumab (also known as HGS-ETR2) is a fully human monoclonal antibody that specifically targets and activates TRAIL receptor 2 (TRAIL-R2, also known as DR5 or TNFRSF10B), a member of the tumor necrosis factor (TNF) receptor superfamily. As an agonist antibody, it binds to DR5 and mimics the action of the natural ligand TRAIL (TNF-related apoptosis-inducing ligand), thereby inducing apoptosis (programmed cell death) in cancer cells that express the receptor. It was developed as a potential therapeutic agent for the treatment of various advanced solid tumors and hematologic malignancies, based on the premise of selectively triggering cell death in tumors while sparing most normal cells.

Synonyms

HGS-ETR2

CAS

845816-02-6

Isotype

IgG1 - lambda

Host

Genetically human

Target

TNFRSF10B/CD262/DR5/TRAILR2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Belyanskaya LL, et al. Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin. Mol Cancer. 2007 Oct 22;6:66.

References 2

Engesæter B, et al. Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma. PLoS One. 2012;7(9):e45492.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/17953743/
https://pubmed.ncbi.nlm.nih.gov/23029050/
https://www.oursmab.com/News/Apoptosis-initiating-receptor-DR5.html

Target Description

Synonyms

tumor necrosis factor receptor (TNFR) superfamily member 10B, death receptor 5, DR5, TNF-related apoptosis-inducing ligand receptor 2, TRAILR2, TRAIL-R2, TR-2, CD262

Biology Area

Apoptosis;Cancer Biology;CD Markers

Function

Death Receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) or TNFRSF10B. DR5 is a cell surface receptor belonging to the Tumor Necrosis Factor (TNF) receptor superfamily. For efficient signal transduction leading to apoptosis, DR5 molecules must aggregate and undergo higher-order clustering at the cell membrane. This clustering recruits crucial adaptor proteins (like FADD) to form the Death-Inducing Signaling Complex (DISC), which then activates caspases (cysteine-aspartic acid proteases) to execute cell death.

Additional Articles 1

Apoptosis-initiating-receptor-DR5

Additional Articles 2

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