Lulizumab (Biosimilar Reference Antibody) (CD28)
Lulizumab (Biosimilar Reference Antibody) (CD28)

Catalog: 

RA0087

Target

CD28

Isotype

V-kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Lulizumab is a humanized anti-CD28 monoclonal antibody engineered as a selective co-stimulation modulator. CD28 is a critical co-stimulatory receptor on T cells. Unlike early superagonistic anti-CD28 antibodies that caused severe cytokine release syndrome, lulizumab is designed to provide a partial or modulated signal upon binding. Its intended mechanism is to fine-tune T-cell activation—potentially enhancing regulatory T cell (Treg) function or providing suboptimal co-stimulation—without inducing massive pro-inflammatory cytokine release. It has been investigated for the treatment of autoimmune and inflammatory diseases, such as lupus and rheumatoid arthritis, where modulating T-cell responses is therapeutic.

Synonyms

BMS-931699

CAS

2235419-62-0

Isotype

V-kappa

Host

Humanised

Target

CD28

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Fernandes JC. Therapeutic application of antibody fragments in autoimmune diseases: current state and prospects. Drug Discov Today. 2018 Dec;23(12):1996-2002.

References 2

Schroder PM, et al. Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model. Kidney Int. 2021 Jan;99(1):161-172.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/29890227/
https://pubmed.ncbi.nlm.nih.gov/32898569/
https://www.oursmab.com/News/T-cell-specific-surface-glycoprotein-CD28.html

Target Description

Synonyms

TP44, T cell specific surface glycoprotein CD28

Biology Area

Immunology;Immune Checkpoint;CD Markers

Function

CD28 is a constitutively expressed co-stimulatory receptor on the surface of T cells. It binds to its ligands B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells (APCs). The signal from CD28, when delivered concurrently with T-cell receptor (TCR) engagement (Signal 1), provides a potent second signal (Signal 2) that is essential for full T-cell activation, proliferation, survival, and cytokine production (e.g., IL-2).

Additional Articles 1

T-cell-specific-surface-glycoprotein-CD28

Additional Articles 2

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