Lumretuzumab (Biosimilar Reference Antibody) (ERBB3)
Lumretuzumab (Biosimilar Reference Antibody) (ERBB3)
Lumretuzumab (Biosimilar Reference Antibody) (ERBB3)-RA0232-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Lumretuzumab (Biosimilar Reference Antibody) (ERBB3)-RA0232 in a linear range of 3.91–31 ng/mL.
Lumretuzumab (Biosimilar Reference Antibody) (ERBB3)

Catalog: 

RA0232

Target

ERBB3/HER3

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Lumretuzumab (also known as RG-7116) is a humanized, glycoengineered monoclonal antibody that targets HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR/ErbB) family. The glycoengineering of its Fc region enhances antibody-dependent cellular cytotoxicity (ADCC). By binding to HER3, lumretuzumab blocks the receptor's ability to dimerize with other ErbB family members (particularly HER2), thereby inhibiting downstream oncogenic signaling pathways such as PI3K/AKT. It was developed as a potential therapeutic agent for HER3-expressing solid tumors, with clinical trials focusing on breast cancer, gastric cancer, and non-small cell lung cancer (NSCLC), often in combination with other agents like pertuzumab (anti-HER2) or chemotherapy.

Synonyms

RG-7116, RG7116, RO5479599

CAS

1448327-63-6

Isotype

IgG1 - kappa

Host

Humanised

Target

ERBB3/HER3

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Schneeweiss A, et al. Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer. Invest New Drugs. 2018 Oct;36(5):848-859.

References 2

Collins D, et al. Direct estrogen receptor (ER) / HER family crosstalk mediating sensitivity to lumretuzumab and pertuzumab in ER+ breast cancer. PLoS One. 2017 May 11;12(5):e0177331.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/29349598/
https://pubmed.ncbi.nlm.nih.gov/28493933/
https://www.oursmab.com/News/Human-epidermal-growth-factor-receptor-HER3.html

Target Description

Synonyms

receptor tyrosine-protein kinase erbB-3, HER3

Biology Area

Cancer Biology;Tumor Antigens

Function

ErbB3 (HER3), a member of the epidermal growth factor receptor (EGFR/ErbB) family of receptor tyrosine kinases. Unlike other ErbB members, ErbB3 has an impaired kinase domain and relies on dimerization with other ErbB partners (especially ErbB2/HER2) for signaling. Its primary ligand is neuregulin. The NRG1-ErbB3-ErbB2 signaling axis is a potent driver of cell proliferation and survival, primarily through activation of the PI3K/AKT pathway. In many cancers, including HNSCC, this pathway is a key mechanism of resistance to therapies targeting EGFR (ErbB1).

Additional Articles 1

Human-epidermal-growth-factor-receptor-HER3

Additional Articles 2

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