Lupartumab (Biosimilar Reference Antibody) (LYPD3)
Lupartumab (Biosimilar Reference Antibody) (LYPD3)
Lupartumab (Biosimilar Reference Antibody) (LYPD3)-RA0472-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Lupartumab (Biosimilar Reference Antibody) (LYPD3)-RA0472 in a linear range of 0.18–15 ng/mL.
Lupartumab (Biosimilar Reference Antibody) (LYPD3)

Catalog: 

RA0472

Target

LYPD3

Isotype

IgG1 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Lupartumab is a human IgG1-lambda2 monoclonal antibody that specifically targets LYPD3 (also known as C4.4A), a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein. As an IgG1 isotype, it is engineered to engage immune effector functions such as antibody-dependent cellular cytotoxicity (ADCC).

Synonyms

BAY 1112623

CAS

1640971-88-5

Isotype

IgG1 - lambda

Host

Genetically human

Target

LYPD3

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Willuda J, et al. Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer. Mol Cancer Ther. 2017 May;16(5):893-904.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/28292941/
https://www.oursmab.com/News/The-target-of-Domain-Containing3-LYPD3.html

Target Description

Synonyms

LY6/PLAUR domain containing 3, C4.4A

Biology Area

Cancer Biology;Cell Adhesion/Migration

Function

LYPD3 is overexpressed in several aggressive cancers. By binding to LYPD3, lupartumab aims to inhibit tumor progression and metastasis, potentially through direct signaling blockade and immune-mediated tumor cell killing. It is being investigated as a therapeutic agent for LYPD3-expressing solid tumors, such as non-small cell lung cancer (NSCLC) and pancreatic cancer.

Additional Articles 1

The-target-of-Domain-Containing3-LYPD3

Additional Articles 2

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