Maridebart (Biosimilar Reference Antibody) (GIPR)
Maridebart (Biosimilar Reference Antibody) (GIPR)
Maridebart (Biosimilar Reference Antibody) (GIPR)-RA0274-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Maridebart (Biosimilar Reference Antibody) (GIPR)-RA0274 in a linear range of 3.91–31 ng/mL.
Maridebart (Biosimilar Reference Antibody) (GIPR)

Catalog: 

RA0274

Target

GIPR

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Maridebart (AMG 133) is an investigational antibody-peptide conjugate designed for the treatment of obesity and type 2 diabetes. Its unique structure consists of a monoclonal antibody scaffold conjugated to engineered peptide modules that confer dual agonism/antagonism: it acts as a glucagon-like peptide-1 (GLP-1) receptor agonist and a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist. This dual mechanism aims to amplify GLP-1-mediated appetite suppression and glycemic control while simultaneously blocking GIP signaling, which is hypothesized to further enhance weight loss. By leveraging the long half-life of an antibody format, it is developed as a once-monthly subcutaneous injection to improve patient adherence.

Synonyms

CAS

2761478-99-1

Isotype

IgG1 - kappa

Host

Genetically human

Target

GIPR

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 4, 2022.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl128.pdf?sfvrsn=889fe54b_3&download=true
https://www.oursmab.com/News/The-glucose-regulatory-receptor-GIPR.html

Target Description

Synonyms

gastric inhibitory polypeptide receptor

Biology Area

Metabolism

Function

The GIP receptor is another GPCR primarily expressed in pancreatic beta cells and adipose tissue. While GIP traditionally acts as an incretin hormone that enhances postprandial insulin secretion, recent evidence suggests that blocking its signaling in the context of obesity may prevent adipose tissue expansion and further promote weight loss, potentially through central effects on appetite regulation.

Additional Articles 1

The-glucose-regulatory-receptor-GIPR

Additional Articles 2

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