Nadecnemab (Biosimilar Reference Antibody) (GFRA3)
Nadecnemab (Biosimilar Reference Antibody) (GFRA3)
Nadecnemab (Biosimilar Reference Antibody) (GFRA3)-RA0273-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Nadecnemab (Biosimilar Reference Antibody) (GFRA3)-RA0273 in a linear range of 0.18–15 ng/mL.
Nadecnemab (Biosimilar Reference Antibody) (GFRA3)

Catalog: 

RA0273

Target

GFRA3

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Nadecnemab is a human IgG4-kappa monoclonal antibody that specifically targets GFRA3 (GDNF family receptor alpha 3), a cell-surface receptor for the glial cell line-derived neurotrophic factor (GDNF) family. As an IgG4 isotype, it is designed to minimize effector functions (e.g., ADCC) and focus on receptor modulation. GFRA3 is involved in pain signaling and joint homeostasis. By binding to GFRA3, nadecnemab aims to inhibit its activation and downstream signaling pathways, thereby reducing pain and potentially modifying disease progression. It is being developed for the treatment of knee osteoarthritis (OA) and associated chronic pain.

Synonyms

REGN5069

CAS

2377679-19-9

Isotype

IgG4 - kappa

Host

Genetically human

Target

GFRA3

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Nadecnemab. Drugbank.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://go.drugbank.com/drugs/DB16677
https://www.oursmab.com/News/The-therapeutic-target-of-neuralgia-GFRA3.html

Target Description

Synonyms

glial cell derived neurotrophic factor family receptor alpha 3, GFRa-3

Biology Area

Neuroscience;Pain Biology

Function

GDNF family receptor alpha 3 (GFRA3) is a glycosylphosphatidylinositol (GPI)-anchored co-receptor that, together with the RET tyrosine kinase, forms the functional receptor complex for artemin (ARTN), a member of the GDNF family of neurotrophic factors. The ARTN–GFRA3–RET signaling axis plays a critical role in the development, survival, and sensitization of peripheral sensory neurons, particularly those involved in pain perception.

Additional Articles 1

The-therapeutic-target-of-neuralgia-GFRA3

Additional Articles 2

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